Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 2455579..2456232 Replicon chromosome
Accession NZ_CP059327
Organism Mannheimia haemolytica strain 0729

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H1D03_RS12190 Protein ID WP_240028655.1
Coordinates 2455843..2456232 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H1D03_RS12185 Protein ID WP_240027552.1
Coordinates 2455579..2455842 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D03_RS12170 (H1D03_12205) 2451267..2454800 + 3534 WP_240027551.1 transcription-repair coupling factor -
H1D03_RS12175 (H1D03_12210) 2454964..2455250 + 287 Protein_2362 BrnT family toxin -
H1D03_RS12180 (H1D03_12215) 2455251..2455463 + 213 WP_006251765.1 BrnA antitoxin family protein -
H1D03_RS12185 (H1D03_12220) 2455579..2455842 + 264 WP_240027552.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
H1D03_RS12190 (H1D03_12225) 2455843..2456232 + 390 WP_240028655.1 type II toxin-antitoxin system VapC family toxin Toxin
H1D03_RS12195 (H1D03_12230) 2456252..2457490 + 1239 WP_006251767.1 peptidase T -
H1D03_RS12235 (H1D03_12270) 2458479..2459264 + 786 WP_240028656.1 GDP-L-fucose synthase -
H1D03_RS12240 (H1D03_12275) 2459338..2460198 + 861 WP_240020774.1 metal ABC transporter permease -
H1D03_RS12245 (H1D03_12280) 2460191..2460999 + 809 Protein_2369 metal ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14412.70 Da        Isoelectric Point: 7.7416

>T168678 WP_240028655.1 NZ_CP059327:2455843-2456232 [Mannheimia haemolytica]
MYMLDTNTVSFFRGNANVVAKLKSINPERLCISSVTAAELVYGVAKRNNGQLSQFLGYFLSSVKVLDWNYRCAELYGKLR
AEMEKNGKVMGVQDQMIASHALAEECILVSSDQAFKMVPDLKLENWLH

Download         Length: 390 bp

>T168678 NZ_CP076225:2316979-2317716 [Bacillus anthracis]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTTCTTGTTTTCTTTTACTGGAGAAATGA
AGAATTGTATGAGGAGAAGAAGCAACGAATTAGAAAGACTTGGTATGGGTTGTTTATAGTATCAGTCACCGTGTATTTCA
TGATAAAAGGAATCGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACGGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATCCGTTCTCAATTTAGTACGATTATTCCGTTAGA
GTACATTGAGCAATTGAATGAGCAGAGAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10373.67 Da        Isoelectric Point: 4.8951

>AT168678 WP_240027552.1 NZ_CP059327:2455579-2455842 [Mannheimia haemolytica]
MEKIARLFRNGRNQAVRLPVEFEFDAEQVYVSKQENGDILLSLRSRNTEHWQRLFELLPAVVCDETFLDTKKERNQSFEQ
RDPFEVA

Download         Length: 264 bp

>AT168678 NZ_CP076225:2317829-2317954 [Bacillus anthracis]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References