Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1945062..1945654 Replicon chromosome
Accession NZ_CP059327
Organism Mannheimia haemolytica strain 0729

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H1D03_RS09720 Protein ID WP_006250491.1
Coordinates 1945226..1945654 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H1D03_RS09715 Protein ID WP_240018773.1
Coordinates 1945062..1945226 (+) Length 55 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D03_RS09700 (H1D03_09710) 1940778..1942493 - 1716 WP_240028550.1 proline--tRNA ligase -
H1D03_RS09705 (H1D03_09715) 1942657..1942842 - 186 WP_240021322.1 hypothetical protein -
H1D03_RS09710 (H1D03_09720) 1942895..1944778 - 1884 WP_240028551.1 molecular chaperone HtpG -
H1D03_RS09715 1945062..1945226 + 165 WP_240018773.1 hypothetical protein Antitoxin
H1D03_RS09720 (H1D03_09730) 1945226..1945654 + 429 WP_006250491.1 type II toxin-antitoxin system VapC family toxin Toxin
H1D03_RS09725 (H1D03_09735) 1945658..1947742 + 2085 WP_240028552.1 ATP-dependent DNA helicase RecG -
H1D03_RS09730 (H1D03_09740) 1947764..1948696 - 933 WP_240027384.1 nucleoside hydrolase -
H1D03_RS09735 (H1D03_09745) 1948748..1950400 - 1653 WP_006250488.1 phospho-sugar mutase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 16640.06 Da        Isoelectric Point: 8.9269

>T168677 WP_006250491.1 NZ_CP059327:1945226-1945654 [Mannheimia haemolytica]
MYRYLFDTNIVSELYKLRNDKMDVNVRQWLRGVNPSQTNISCITLSEIKTGILLKARKDKEQSDRLNDWFENNVLKAYQT
KAFVVNNDIALLASEYHIPNKMDLNDAYIAATAKYHNLILVTRNTKDFIRCDVRLFNPFETA

Download         Length: 429 bp

>T168677 NZ_CP076225:241541-241891 [Bacillus anthracis]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGTGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin


Download         Length: 55 a.a.        Molecular weight: 6443.93 Da        Isoelectric Point: 3.8960

>AT168677 WP_240018773.1 NZ_CP059327:1945062-1945226 [Mannheimia haemolytica]
MDYQQKKPSEPSFEELFASSENEDVSDEFWQEFEQTLVEIRKSNKPRPVDFGDE

Download         Length: 165 bp

>AT168677 NZ_CP076225:241249-241536 [Bacillus anthracis]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References