Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicB(antitoxin) |
| Location | 1333073..1333713 | Replicon | chromosome |
| Accession | NZ_CP059327 | ||
| Organism | Mannheimia haemolytica strain 0729 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A378NFX7 |
| Locus tag | H1D03_RS06400 | Protein ID | WP_006250075.1 |
| Coordinates | 1333073..1333255 (+) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | A0A378NET2 |
| Locus tag | H1D03_RS06405 | Protein ID | WP_006250984.1 |
| Coordinates | 1333294..1333713 (+) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H1D03_RS06365 (H1D03_06390) | 1328640..1329686 | - | 1047 | WP_240028401.1 | conserved phage C-terminal domain-containing protein | - |
| H1D03_RS06370 (H1D03_06395) | 1329683..1330522 | - | 840 | WP_006252350.1 | Rha family transcriptional regulator | - |
| H1D03_RS06375 (H1D03_06400) | 1330697..1330957 | - | 261 | WP_240028402.1 | CII family transcriptional regulator | - |
| H1D03_RS06380 (H1D03_06405) | 1330978..1331178 | - | 201 | WP_006248825.1 | YdaS family helix-turn-helix protein | - |
| H1D03_RS06385 (H1D03_06410) | 1331309..1331998 | + | 690 | WP_240028403.1 | S24 family peptidase | - |
| H1D03_RS06390 (H1D03_06415) | 1332073..1332453 | + | 381 | WP_006248823.1 | hypothetical protein | - |
| H1D03_RS06395 | 1332446..1332676 | + | 231 | WP_240028131.1 | hypothetical protein | - |
| H1D03_RS06400 (H1D03_06425) | 1333073..1333255 | + | 183 | WP_006250075.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| H1D03_RS06405 (H1D03_06430) | 1333294..1333713 | + | 420 | WP_006250984.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| H1D03_RS06410 (H1D03_06435) | 1333779..1334084 | - | 306 | WP_006250985.1 | HigA family addiction module antitoxin | - |
| H1D03_RS06415 (H1D03_06440) | 1334093..1334368 | - | 276 | WP_006250986.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| H1D03_RS06420 (H1D03_06445) | 1334657..1334887 | + | 231 | WP_006250987.1 | hypothetical protein | - |
| H1D03_RS06425 (H1D03_06450) | 1335366..1335689 | - | 324 | WP_006250988.1 | hypothetical protein | - |
| H1D03_RS06430 (H1D03_06455) | 1335882..1336067 | + | 186 | WP_020824222.1 | hypothetical protein | - |
| H1D03_RS06435 (H1D03_06460) | 1336051..1336215 | + | 165 | WP_020824223.1 | hypothetical protein | - |
| H1D03_RS06440 (H1D03_06465) | 1336221..1336679 | + | 459 | WP_240028132.1 | single-stranded DNA-binding protein | - |
| H1D03_RS06445 (H1D03_06470) | 1336715..1337074 | + | 360 | WP_006250991.1 | hypothetical protein | - |
| H1D03_RS06450 (H1D03_06475) | 1337146..1337949 | + | 804 | WP_020824224.1 | DUF2303 family protein | - |
| H1D03_RS06455 (H1D03_06480) | 1338001..1338435 | + | 435 | WP_020824225.1 | DUF6378 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1272051..1343518 | 71467 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6933.03 Da Isoelectric Point: 10.3446
>T168673 WP_006250075.1 NZ_CP059327:1333073-1333255 [Mannheimia haemolytica]
MKYSEFLRYLLAQGCEIENHRRGSHRKVTLNGKQSVFPYHGSKEIGTGLVNKIKKDLDLK
MKYSEFLRYLLAQGCEIENHRRGSHRKVTLNGKQSVFPYHGSKEIGTGLVNKIKKDLDLK
Download Length: 183 bp
>T168673 NZ_CP076219:241242-241592 [Bacillus anthracis]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGTGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGTGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA
Antitoxin
Download Length: 140 a.a. Molecular weight: 15957.34 Da Isoelectric Point: 4.6983
>AT168673 WP_006250984.1 NZ_CP059327:1333294-1333713 [Mannheimia haemolytica]
MLRYPVEITPDDNGTYLVTCPDIPEMASVGEDLEEALLEAQDGLATALEFYFDDRREIPMPSPIKEGQHTVNLTVLQSMK
VFLLNEMIKQGVRKAEMARRLDVHLPQIDRLLDFNHSTKVEFVEKAYGKLNQRFTILPH
MLRYPVEITPDDNGTYLVTCPDIPEMASVGEDLEEALLEAQDGLATALEFYFDDRREIPMPSPIKEGQHTVNLTVLQSMK
VFLLNEMIKQGVRKAEMARRLDVHLPQIDRLLDFNHSTKVEFVEKAYGKLNQRFTILPH
Download Length: 420 bp
>AT168673 NZ_CP076219:240950-241237 [Bacillus anthracis]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A378NFX7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A378NET2 |