Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 1493285..1493890 Replicon chromosome
Accession NZ_CP059326
Organism Mannheimia haemolytica strain 0745

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H1D04_RS07635 Protein ID WP_240028655.1
Coordinates 1493501..1493890 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H1D04_RS07630 Protein ID WP_240021157.1
Coordinates 1493285..1493500 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D04_RS07615 (H1D04_07560) 1488926..1492462 + 3537 WP_275686262.1 transcription-repair coupling factor -
H1D04_RS07620 (H1D04_07565) 1492626..1492912 + 287 Protein_1452 BrnT family toxin -
H1D04_RS07625 (H1D04_07570) 1492913..1493125 + 213 WP_006251765.1 BrnA antitoxin family protein -
H1D04_RS07630 (H1D04_07575) 1493285..1493500 + 216 WP_240021157.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
H1D04_RS07635 (H1D04_07580) 1493501..1493890 + 390 WP_240028655.1 type II toxin-antitoxin system VapC family toxin Toxin
H1D04_RS07640 (H1D04_07585) 1493910..1495148 + 1239 WP_006251767.1 peptidase T -
H1D04_RS07680 (H1D04_07625) 1496139..1496927 + 789 WP_275686263.1 GDP-L-fucose synthase -
H1D04_RS07685 (H1D04_07630) 1497001..1497861 + 861 WP_240020774.1 metal ABC transporter permease -
H1D04_RS07690 (H1D04_07635) 1497854..1498661 + 808 Protein_1459 metal ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14412.70 Da        Isoelectric Point: 7.7416

>T168669 WP_240028655.1 NZ_CP059326:1493501-1493890 [Mannheimia haemolytica]
MYMLDTNTVSFFRGNANVVAKLKSINPERLCISSVTAAELVYGVAKRNNGQLSQFLGYFLSSVKVLDWNYRCAELYGKLR
AEMEKNGKVMGVQDQMIASHALAEECILVSSDQAFKMVPDLKLENWLH

Download         Length: 390 bp

>T168669 NZ_CP076213:241542-241892 [Bacillus anthracis]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGTGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8459.41 Da        Isoelectric Point: 4.2340

>AT168669 WP_240021157.1 NZ_CP059326:1493285-1493500 [Mannheimia haemolytica]
VRLPVEFEFDAEQVYVSKQENGDILLSLRSRNTEHWQRLFELLPAVVCDETFLDTKERNQSFEQRDPFEVA

Download         Length: 216 bp

>AT168669 NZ_CP076213:241250-241537 [Bacillus anthracis]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References