Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 703416..704064 Replicon chromosome
Accession NZ_CP059326
Organism Mannheimia haemolytica strain 0745

Toxin (Protein)


Gene name hicA Uniprot ID A0A249A099
Locus tag H1D04_RS03710 Protein ID WP_006251221.1
Coordinates 703888..704064 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A248ZZL6
Locus tag H1D04_RS03705 Protein ID WP_006251222.1
Coordinates 703416..703832 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D04_RS03670 (H1D04_03645) 699738..700172 + 435 WP_006251230.1 hypothetical protein -
H1D04_RS03675 (H1D04_03650) 700187..701173 + 987 WP_240028255.1 encapsulin -
H1D04_RS03680 (H1D04_03655) 701185..701418 + 234 WP_075271287.1 hypothetical protein -
H1D04_RS03685 701973..702143 + 171 WP_021280623.1 hypothetical protein -
H1D04_RS03690 (H1D04_03670) 702145..702513 + 369 WP_006251225.1 hypothetical protein -
H1D04_RS03695 (H1D04_03675) 702510..702890 + 381 WP_240017575.1 hypothetical protein -
H1D04_RS03700 (H1D04_03680) 702894..703376 + 483 WP_006251223.1 phage tail tube protein -
H1D04_RS03705 (H1D04_03685) 703416..703832 - 417 WP_006251222.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H1D04_RS03710 (H1D04_03690) 703888..704064 - 177 WP_006251221.1 type II toxin-antitoxin system HicA family toxin Toxin
H1D04_RS03715 (H1D04_03695) 704166..704831 + 666 WP_275686743.1 DUF6246 family protein -
H1D04_RS03720 (H1D04_03700) 704846..705115 - 270 WP_006251219.1 hypothetical protein -
H1D04_RS03725 (H1D04_03705) 705248..705706 + 459 WP_275686744.1 hypothetical protein -
H1D04_RS03730 (H1D04_03710) 705773..706168 + 396 WP_006251217.1 hypothetical protein -
H1D04_RS03735 (H1D04_03715) 706255..708750 + 2496 WP_275686745.1 phage tail length tape measure family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 663961..717732 53771


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-64)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6640.79 Da        Isoelectric Point: 10.7708

>T168666 WP_006251221.1 NZ_CP059326:c704064-703888 [Mannheimia haemolytica]
VKQSEFLRWLKANGVEVENGSKHLKLYYKGKRSHLPKHPSQELKTGLVEGVKKQLGLK

Download         Length: 177 bp

>T168666 NZ_CP076207:2316778-2317515 [Bacillus anthracis]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTTCTTGTTTTCTTTTACTGGAGAAATGA
AGAATTGTATGAGGAGAAGAAGCAACGAATTAGAAAGACTTGGTATGGGTTGTTTATAGTATCAGTCACCGTGTATTTCA
TGATAAAAGGAATCGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACGGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATCCGTTCTCAATTTAGTACGATTATTCCGTTAGA
GTACATTGAGCAATTGAATGAGCAGAGAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15519.91 Da        Isoelectric Point: 4.3508

>AT168666 WP_006251222.1 NZ_CP059326:c703832-703416 [Mannheimia haemolytica]
MFYPALFTPAEEGGFVVTFPDLPEAITQGDTFEEAMEMAEDVLLSCVEIYFDEDRRFPLTRPVNTDEVPVFMPESIYAKV
LLHNTMQEQAVSKAEIARLTNIRPPEVQRILAPRHITKIDTIGRILASLGKPLQLSLG

Download         Length: 417 bp

>AT168666 NZ_CP076207:2317628-2317753 [Bacillus anthracis]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249A099

Antitoxin

Source ID Structure
AlphaFold DB A0A248ZZL6

References