Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 370901..371541 Replicon chromosome
Accession NZ_CP059326
Organism Mannheimia haemolytica strain 0745

Toxin (Protein)


Gene name hicA Uniprot ID A0A378NFX7
Locus tag H1D04_RS01815 Protein ID WP_006250075.1
Coordinates 370901..371083 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A378NET2
Locus tag H1D04_RS01820 Protein ID WP_006250984.1
Coordinates 371122..371541 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D04_RS01780 (H1D04_01760) 366469..367515 - 1047 WP_275686646.1 conserved phage C-terminal domain-containing protein -
H1D04_RS01785 (H1D04_01765) 367512..368351 - 840 WP_006252350.1 Rha family transcriptional regulator -
H1D04_RS01790 (H1D04_01770) 368526..368786 - 261 WP_240028402.1 CII family transcriptional regulator -
H1D04_RS01795 (H1D04_01775) 368807..369007 - 201 WP_006248825.1 YdaS family helix-turn-helix protein -
H1D04_RS01800 (H1D04_01780) 369138..369827 + 690 WP_275686647.1 S24 family peptidase -
H1D04_RS01805 (H1D04_01785) 369902..370282 + 381 WP_006248823.1 hypothetical protein -
H1D04_RS01810 370287..370505 + 219 WP_240029999.1 hypothetical protein -
H1D04_RS01815 (H1D04_01795) 370901..371083 + 183 WP_006250075.1 type II toxin-antitoxin system HicA family toxin Toxin
H1D04_RS01820 (H1D04_01800) 371122..371541 + 420 WP_006250984.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H1D04_RS01825 (H1D04_01805) 371608..371913 - 306 WP_006250985.1 HigA family addiction module antitoxin -
H1D04_RS01830 (H1D04_01810) 371922..372197 - 276 WP_006250986.1 type II toxin-antitoxin system RelE/ParE family toxin -
H1D04_RS01835 (H1D04_01815) 372485..372715 + 231 WP_006250987.1 hypothetical protein -
H1D04_RS01840 (H1D04_01820) 373194..373517 - 324 WP_006250988.1 hypothetical protein -
H1D04_RS01845 (H1D04_01825) 373709..373894 + 186 WP_020824222.1 hypothetical protein -
H1D04_RS01850 (H1D04_01830) 373878..374042 + 165 WP_020824223.1 hypothetical protein -
H1D04_RS01855 (H1D04_01835) 374048..374506 + 459 WP_240028132.1 single-stranded DNA-binding protein -
H1D04_RS01860 (H1D04_01840) 374542..374901 + 360 WP_006250991.1 hypothetical protein -
H1D04_RS01865 (H1D04_01845) 374973..375776 + 804 WP_020824224.1 DUF2303 family protein -
H1D04_RS01870 (H1D04_01850) 375827..376261 + 435 WP_020824225.1 DUF6378 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 300133..381845 81712


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-96)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6933.03 Da        Isoelectric Point: 10.3446

>T168664 WP_006250075.1 NZ_CP059326:370901-371083 [Mannheimia haemolytica]
MKYSEFLRYLLAQGCEIENHRRGSHRKVTLNGKQSVFPYHGSKEIGTGLVNKIKKDLDLK

Download         Length: 183 bp

>T168664 NZ_CP076204:2316897-2317634 [Bacillus anthracis]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTTCTTGTTTTCTTTTACTGGAGAAATGA
AGAATTGTATGAGGAGAAGAAGCAACGAATTAGAAAGACTTGGTATGGGTTGTTTATAGTATCAGTCACCGTGTATTTCA
TGATAAAAGGAATCGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACGGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATCCGTTCTCAATTTAGTACGATTATTCCGTTAGA
GTACATTGAGCAATTGAATGAGCAGAGAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15957.34 Da        Isoelectric Point: 4.6983

>AT168664 WP_006250984.1 NZ_CP059326:371122-371541 [Mannheimia haemolytica]
MLRYPVEITPDDNGTYLVTCPDIPEMASVGEDLEEALLEAQDGLATALEFYFDDRREIPMPSPIKEGQHTVNLTVLQSMK
VFLLNEMIKQGVRKAEMARRLDVHLPQIDRLLDFNHSTKVEFVEKAYGKLNQRFTILPH

Download         Length: 420 bp

>AT168664 NZ_CP076204:2317747-2317872 [Bacillus anthracis]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378NFX7

Antitoxin

Source ID Structure
AlphaFold DB A0A378NET2

References