Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/UPF0150(antitoxin) |
| Location | 2261052..2261665 | Replicon | chromosome |
| Accession | NZ_CP059325 | ||
| Organism | Mannheimia haemolytica strain 0746 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A249A099 |
| Locus tag | H1D05_RS11270 | Protein ID | WP_006251221.1 |
| Coordinates | 2261052..2261228 (+) | Length | 59 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | H1D05_RS11275 | Protein ID | WP_240019662.1 |
| Coordinates | 2261282..2261665 (+) | Length | 128 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H1D05_RS11220 | 2256373..2256612 | - | 240 | WP_240019654.1 | hypothetical protein | - |
| H1D05_RS11225 | 2256938..2257159 | - | 222 | WP_240019655.1 | hypothetical protein | - |
| H1D05_RS11230 | 2257159..2257515 | - | 357 | WP_240019656.1 | hypothetical protein | - |
| H1D05_RS11235 | 2257595..2258026 | - | 432 | WP_240019657.1 | hypothetical protein | - |
| H1D05_RS11240 | 2258366..2258821 | - | 456 | WP_240019658.1 | phage tail length tape measure family protein | - |
| H1D05_RS11245 (H1D05_11190) | 2258951..2259343 | - | 393 | WP_240019659.1 | hypothetical protein | - |
| H1D05_RS11250 | 2259727..2259867 | - | 141 | WP_240019660.1 | hypothetical protein | - |
| H1D05_RS11255 (H1D05_11200) | 2260038..2260271 | + | 234 | WP_020824316.1 | hypothetical protein | - |
| H1D05_RS14155 | 2260286..2260438 | - | 153 | WP_275672143.1 | DUF6246 family protein | - |
| H1D05_RS14160 | 2260560..2260685 | - | 126 | WP_275672144.1 | DUF6246 family protein | - |
| H1D05_RS11265 | 2260691..2260951 | - | 261 | WP_240019661.1 | DUF6246 family protein | - |
| H1D05_RS11270 (H1D05_11210) | 2261052..2261228 | + | 177 | WP_006251221.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| H1D05_RS11275 (H1D05_11215) | 2261282..2261665 | + | 384 | WP_240019662.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| H1D05_RS11280 | 2261738..2261986 | - | 249 | WP_240019663.1 | hypothetical protein | - |
| H1D05_RS11285 (H1D05_11225) | 2262225..2262605 | - | 381 | WP_006251224.1 | hypothetical protein | - |
| H1D05_RS11290 (H1D05_11230) | 2262602..2262970 | - | 369 | WP_006251225.1 | hypothetical protein | - |
| H1D05_RS11295 | 2262972..2263142 | - | 171 | WP_021280623.1 | hypothetical protein | - |
| H1D05_RS11300 (H1D05_11240) | 2263392..2263694 | - | 303 | WP_240019664.1 | hypothetical protein | - |
| H1D05_RS11305 (H1D05_11245) | 2263707..2263973 | - | 267 | WP_240019665.1 | hypothetical protein | - |
| H1D05_RS14165 | 2263985..2264476 | - | 492 | WP_275672145.1 | DUF6260 family protein | - |
| H1D05_RS14170 | 2264494..2264898 | - | 405 | WP_275672146.1 | DUF6260 family protein | - |
| H1D05_RS11315 (H1D05_11255) | 2264990..2265421 | - | 432 | WP_240019666.1 | hypothetical protein | - |
| H1D05_RS11320 | 2265414..2265842 | - | 429 | WP_240019667.1 | hypothetical protein | - |
| H1D05_RS11325 | 2265910..2266182 | - | 273 | WP_240019668.1 | hypothetical protein | - |
| H1D05_RS11330 | 2266205..2266660 | - | 456 | WP_240019669.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2243345..2368442 | 125097 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6640.79 Da Isoelectric Point: 10.7708
>T168661 WP_006251221.1 NZ_CP059325:2261052-2261228 [Mannheimia haemolytica]
VKQSEFLRWLKANGVEVENGSKHLKLYYKGKRSHLPKHPSQELKTGLVEGVKKQLGLK
VKQSEFLRWLKANGVEVENGSKHLKLYYKGKRSHLPKHPSQELKTGLVEGVKKQLGLK
Download Length: 177 bp
>T168661 NZ_CP076201:241566-241916 [Bacillus anthracis]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGCGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGCGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA
Antitoxin
Download Length: 128 a.a. Molecular weight: 14445.58 Da Isoelectric Point: 4.2616
>AT168661 WP_240019662.1 NZ_CP059325:2261282-2261665 [Mannheimia haemolytica]
MFYPALFTPAEEGGFVVTFPDLPEAITQGDTFEEAMEMAEDVLLSCVEIYFDEDRRFPLTRPVNTDEVPVFMPESIYAKV
LLHNTMQEQAVSKAEIARLTNIRPPEVQRILAPRHITKIDTIGRIFG
MFYPALFTPAEEGGFVVTFPDLPEAITQGDTFEEAMEMAEDVLLSCVEIYFDEDRRFPLTRPVNTDEVPVFMPESIYAKV
LLHNTMQEQAVSKAEIARLTNIRPPEVQRILAPRHITKIDTIGRIFG
Download Length: 384 bp
>AT168661 NZ_CP076201:241274-241561 [Bacillus anthracis]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|