Detailed information of TA system TA168657

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 793861..794453
• Replicon: chromosome
• Accession: NZ_CP059325
• Organism: Mannheimia haemolytica strain 0746

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: H1D05_RS03955
• Protein ID: WP_006250491.1
• Coordinates: 794025..794453 (+)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: H1D05_RS03950
• Protein ID: WP_240018773.1
• Coordinates: 793861..794025 (+)
• Length: 55 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H1D05_RS03935 (H1D05_03910)	789602..791317	-	1716	WP_240020400.1	proline--tRNA ligase	-
H1D05_RS03940 (H1D05_03915)	791480..791641	-	162	WP_240020401.1	hypothetical protein	-
H1D05_RS03945 (H1D05_03920)	791694..793577	-	1884	WP_240020402.1	molecular chaperone HtpG	-
H1D05_RS03950	793861..794025	+	165	WP_240018773.1	hypothetical protein	Antitoxin
H1D05_RS03955 (H1D05_03930)	794025..794453	+	429	WP_006250491.1	type II toxin-antitoxin system VapC family toxin	Toxin
H1D05_RS03960 (H1D05_03935)	794457..796538	+	2082	WP_006248274.1	ATP-dependent DNA helicase RecG	-
H1D05_RS03965 (H1D05_03940)	796560..797495	-	936	WP_240020403.1	nucleoside hydrolase	-
H1D05_RS03970 (H1D05_03945)	797547..799202	-	1656	WP_240020404.1	phospho-sugar mutase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-129)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 16640.06 Da
• Isoelectric Point: 8.9269

>T168657 WP_006250491.1 NZ_CP059325:794025-794453 [Mannheimia haemolytica]
MYRYLFDTNIVSELYKLRNDKMDVNVRQWLRGVNPSQTNISCITLSEIKTGILLKARKDKEQSDRLNDWFENNVLKAYQT
KAFVVNNDIALLASEYHIPNKMDLNDAYIAATAKYHNLILVTRNTKDFIRCDVRLFNPFETA

Nucleotide

• Length: 429 bp

>T168657 NZ_CP076195:241085-241435 [Bacillus anthracis]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGTGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin

Protein

• Length: 55 a.a.
• Molecular weight: 6443.93 Da
• Isoelectric Point: 3.8960

>AT168657 WP_240018773.1 NZ_CP059325:793861-794025 [Mannheimia haemolytica]
MDYQQKKPSEPSFEELFASSENEDVSDEFWQEFEQTLVEIRKSNKPRPVDFGDE

Nucleotide

• Length: 165 bp

>AT168657 NZ_CP076195:240793-241080 [Bacillus anthracis]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA