Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicB(antitoxin) |
| Location | 1770711..1771351 | Replicon | chromosome |
| Accession | NZ_CP059324 | ||
| Organism | Mannheimia haemolytica strain 0760 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A378NFX7 |
| Locus tag | H1D06_RS08980 | Protein ID | WP_006250075.1 |
| Coordinates | 1771169..1771351 (-) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | A0A378NET2 |
| Locus tag | H1D06_RS08975 | Protein ID | WP_006250984.1 |
| Coordinates | 1770711..1771130 (-) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H1D06_RS08925 (H1D06_08925) | 1765990..1766424 | - | 435 | WP_020824225.1 | DUF6378 domain-containing protein | - |
| H1D06_RS08930 (H1D06_08930) | 1766476..1767279 | - | 804 | WP_240017754.1 | DUF2303 family protein | - |
| H1D06_RS08935 (H1D06_08935) | 1767351..1767710 | - | 360 | WP_006250991.1 | hypothetical protein | - |
| H1D06_RS08940 (H1D06_08940) | 1767746..1768204 | - | 459 | WP_240017755.1 | single-stranded DNA-binding protein | - |
| H1D06_RS08945 (H1D06_08945) | 1768210..1768374 | - | 165 | WP_020824223.1 | hypothetical protein | - |
| H1D06_RS08950 (H1D06_08950) | 1768358..1768543 | - | 186 | WP_020824222.1 | hypothetical protein | - |
| H1D06_RS08955 (H1D06_08955) | 1768735..1769058 | + | 324 | WP_006250988.1 | hypothetical protein | - |
| H1D06_RS08960 (H1D06_08960) | 1769537..1769767 | - | 231 | WP_006250987.1 | hypothetical protein | - |
| H1D06_RS08965 (H1D06_08965) | 1770055..1770330 | + | 276 | WP_006250986.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| H1D06_RS08970 (H1D06_08970) | 1770339..1770644 | + | 306 | WP_006250985.1 | HigA family addiction module antitoxin | - |
| H1D06_RS08975 (H1D06_08975) | 1770711..1771130 | - | 420 | WP_006250984.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| H1D06_RS08980 (H1D06_08980) | 1771169..1771351 | - | 183 | WP_006250075.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| H1D06_RS08985 (H1D06_08990) | 1772002..1772352 | - | 351 | WP_236964885.1 | hypothetical protein | - |
| H1D06_RS08990 (H1D06_08995) | 1772427..1773113 | - | 687 | WP_240017756.1 | S24 family peptidase | - |
| H1D06_RS08995 (H1D06_09000) | 1773244..1773444 | + | 201 | WP_006248825.1 | YdaS family helix-turn-helix protein | - |
| H1D06_RS09000 (H1D06_09005) | 1773465..1773725 | + | 261 | WP_006252483.1 | CII family transcriptional regulator | - |
| H1D06_RS09005 (H1D06_09010) | 1773900..1774739 | + | 840 | WP_006252350.1 | Rha family transcriptional regulator | - |
| H1D06_RS09010 (H1D06_09015) | 1774736..1775782 | + | 1047 | WP_240017757.1 | conserved phage C-terminal domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1760908..1813916 | 53008 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6933.03 Da Isoelectric Point: 10.3446
>T168653 WP_006250075.1 NZ_CP059324:c1771351-1771169 [Mannheimia haemolytica]
MKYSEFLRYLLAQGCEIENHRRGSHRKVTLNGKQSVFPYHGSKEIGTGLVNKIKKDLDLK
MKYSEFLRYLLAQGCEIENHRRGSHRKVTLNGKQSVFPYHGSKEIGTGLVNKIKKDLDLK
Download Length: 183 bp
>T168653 NZ_CP076190:241762-242112 [Bacillus anthracis]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGTGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGTGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA
Antitoxin
Download Length: 140 a.a. Molecular weight: 15957.34 Da Isoelectric Point: 4.6983
>AT168653 WP_006250984.1 NZ_CP059324:c1771130-1770711 [Mannheimia haemolytica]
MLRYPVEITPDDNGTYLVTCPDIPEMASVGEDLEEALLEAQDGLATALEFYFDDRREIPMPSPIKEGQHTVNLTVLQSMK
VFLLNEMIKQGVRKAEMARRLDVHLPQIDRLLDFNHSTKVEFVEKAYGKLNQRFTILPH
MLRYPVEITPDDNGTYLVTCPDIPEMASVGEDLEEALLEAQDGLATALEFYFDDRREIPMPSPIKEGQHTVNLTVLQSMK
VFLLNEMIKQGVRKAEMARRLDVHLPQIDRLLDFNHSTKVEFVEKAYGKLNQRFTILPH
Download Length: 420 bp
>AT168653 NZ_CP076190:241470-241757 [Bacillus anthracis]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A378NFX7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A378NET2 |