Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1158890..1159482 Replicon chromosome
Accession NZ_CP059324
Organism Mannheimia haemolytica strain 0760

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H1D06_RS05660 Protein ID WP_006250491.1
Coordinates 1158890..1159318 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H1D06_RS05665 Protein ID WP_240018773.1
Coordinates 1159318..1159482 (-) Length 55 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D06_RS05645 (H1D06_05655) 1154148..1155800 + 1653 WP_006250488.1 phospho-sugar mutase -
H1D06_RS05650 (H1D06_05660) 1155800..1156783 + 984 WP_240018772.1 nucleoside hydrolase -
H1D06_RS05655 (H1D06_05665) 1156805..1158886 - 2082 WP_006250490.1 ATP-dependent DNA helicase RecG -
H1D06_RS05660 (H1D06_05670) 1158890..1159318 - 429 WP_006250491.1 type II toxin-antitoxin system VapC family toxin Toxin
H1D06_RS05665 1159318..1159482 - 165 WP_240018773.1 hypothetical protein Antitoxin
H1D06_RS05670 (H1D06_05680) 1159766..1161649 + 1884 WP_240018774.1 molecular chaperone HtpG -
H1D06_RS05675 (H1D06_05685) 1161702..1161884 + 183 WP_006250493.1 hypothetical protein -
H1D06_RS05680 (H1D06_05690) 1162047..1163762 + 1716 WP_240018775.1 proline--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 16640.06 Da        Isoelectric Point: 8.9269

>T168649 WP_006250491.1 NZ_CP059324:c1159318-1158890 [Mannheimia haemolytica]
MYRYLFDTNIVSELYKLRNDKMDVNVRQWLRGVNPSQTNISCITLSEIKTGILLKARKDKEQSDRLNDWFENNVLKAYQT
KAFVVNNDIALLASEYHIPNKMDLNDAYIAATAKYHNLILVTRNTKDFIRCDVRLFNPFETA

Download         Length: 429 bp

>T168649 NZ_CP076184:241541-241891 [Bacillus anthracis]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGTGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin


Download         Length: 55 a.a.        Molecular weight: 6443.93 Da        Isoelectric Point: 3.8960

>AT168649 WP_240018773.1 NZ_CP059324:c1159482-1159318 [Mannheimia haemolytica]
MDYQQKKPSEPSFEELFASSENEDVSDEFWQEFEQTLVEIRKSNKPRPVDFGDE

Download         Length: 165 bp

>AT168649 NZ_CP076184:241249-241536 [Bacillus anthracis]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References