Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2197248..2197840 Replicon chromosome
Accession NZ_CP059323
Organism Mannheimia haemolytica strain 0768

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H1D07_RS10675 Protein ID WP_006250491.1
Coordinates 2197248..2197676 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H1D07_RS10680 Protein ID WP_240018773.1
Coordinates 2197676..2197840 (-) Length 55 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D07_RS10660 (H1D07_10720) 2192506..2194158 + 1653 WP_240026840.1 phospho-sugar mutase -
H1D07_RS10665 (H1D07_10725) 2194158..2195141 + 984 WP_240026841.1 nucleoside hydrolase -
H1D07_RS10670 (H1D07_10730) 2195163..2197244 - 2082 WP_006250490.1 ATP-dependent DNA helicase RecG -
H1D07_RS10675 (H1D07_10735) 2197248..2197676 - 429 WP_006250491.1 type II toxin-antitoxin system VapC family toxin Toxin
H1D07_RS10680 2197676..2197840 - 165 WP_240018773.1 hypothetical protein Antitoxin
H1D07_RS10685 (H1D07_10745) 2198124..2200007 + 1884 WP_240026842.1 molecular chaperone HtpG -
H1D07_RS10690 (H1D07_10750) 2200060..2200242 + 183 WP_006250493.1 hypothetical protein -
H1D07_RS10695 (H1D07_10755) 2200405..2202120 + 1716 WP_240024853.1 proline--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 16640.06 Da        Isoelectric Point: 8.9269

>T168644 WP_006250491.1 NZ_CP059323:c2197676-2197248 [Mannheimia haemolytica]
MYRYLFDTNIVSELYKLRNDKMDVNVRQWLRGVNPSQTNISCITLSEIKTGILLKARKDKEQSDRLNDWFENNVLKAYQT
KAFVVNNDIALLASEYHIPNKMDLNDAYIAATAKYHNLILVTRNTKDFIRCDVRLFNPFETA

Download         Length: 429 bp

>T168644 NZ_CP076176:2316876-2317613 [Bacillus anthracis]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTTCTTGTTTTCTTTTACTGGAGAAATGA
AGAATTGTATGAGGAGAAGAAGCAACGAATTAGAAAGACTTGGTATGGGTTGTTTATAGTATCAGTCACCGTGTATTTCA
TGATAAAAGGAATCGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACGGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATCCGTTCTCAATTTAGTACGATTATTCCGTTAGA
GTACATTGAGCAATTGAATGAGCAGAGAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 55 a.a.        Molecular weight: 6443.93 Da        Isoelectric Point: 3.8960

>AT168644 WP_240018773.1 NZ_CP059323:c2197840-2197676 [Mannheimia haemolytica]
MDYQQKKPSEPSFEELFASSENEDVSDEFWQEFEQTLVEIRKSNKPRPVDFGDE

Download         Length: 165 bp

>AT168644 NZ_CP076176:2317726-2317851 [Bacillus anthracis]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References