Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicB(antitoxin) |
| Location | 218645..219285 | Replicon | chromosome |
| Accession | NZ_CP059323 | ||
| Organism | Mannheimia haemolytica strain 0768 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A378NFX7 |
| Locus tag | H1D07_RS01165 | Protein ID | WP_006250075.1 |
| Coordinates | 219103..219285 (-) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | A0A378NET2 |
| Locus tag | H1D07_RS01160 | Protein ID | WP_006250984.1 |
| Coordinates | 218645..219064 (-) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H1D07_RS01110 (H1D07_01095) | 213925..214359 | - | 435 | WP_020824225.1 | DUF6378 domain-containing protein | - |
| H1D07_RS01115 (H1D07_01100) | 214411..215214 | - | 804 | WP_240017754.1 | DUF2303 family protein | - |
| H1D07_RS01120 (H1D07_01105) | 215286..215645 | - | 360 | WP_006250991.1 | hypothetical protein | - |
| H1D07_RS01125 (H1D07_01110) | 215681..216139 | - | 459 | WP_240017755.1 | single-stranded DNA-binding protein | - |
| H1D07_RS01130 (H1D07_01115) | 216145..216309 | - | 165 | WP_020824223.1 | hypothetical protein | - |
| H1D07_RS01135 (H1D07_01120) | 216293..216478 | - | 186 | WP_020824222.1 | hypothetical protein | - |
| H1D07_RS01140 (H1D07_01125) | 216670..216993 | + | 324 | WP_006250988.1 | hypothetical protein | - |
| H1D07_RS01145 (H1D07_01130) | 217472..217702 | - | 231 | WP_006250987.1 | hypothetical protein | - |
| H1D07_RS01150 (H1D07_01135) | 217990..218265 | + | 276 | WP_006250986.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| H1D07_RS01155 (H1D07_01140) | 218274..218579 | + | 306 | WP_006250985.1 | HigA family addiction module antitoxin | - |
| H1D07_RS01160 (H1D07_01145) | 218645..219064 | - | 420 | WP_006250984.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| H1D07_RS01165 (H1D07_01150) | 219103..219285 | - | 183 | WP_006250075.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| H1D07_RS01170 (H1D07_01160) | 219937..220287 | - | 351 | WP_236964885.1 | hypothetical protein | - |
| H1D07_RS01175 (H1D07_01165) | 220362..221048 | - | 687 | WP_240026987.1 | S24 family peptidase | - |
| H1D07_RS01180 | 221292..221378 | + | 87 | WP_240021820.1 | helix-turn-helix domain-containing protein | - |
| H1D07_RS01185 (H1D07_01175) | 221399..221659 | + | 261 | WP_006252483.1 | CII family transcriptional regulator | - |
| H1D07_RS01190 (H1D07_01180) | 221833..222672 | + | 840 | WP_006252350.1 | Rha family transcriptional regulator | - |
| H1D07_RS01195 (H1D07_01185) | 222669..223715 | + | 1047 | WP_240026988.1 | conserved phage C-terminal domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 208347..280269 | 71922 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6933.03 Da Isoelectric Point: 10.3446
>T168641 WP_006250075.1 NZ_CP059323:c219285-219103 [Mannheimia haemolytica]
MKYSEFLRYLLAQGCEIENHRRGSHRKVTLNGKQSVFPYHGSKEIGTGLVNKIKKDLDLK
MKYSEFLRYLLAQGCEIENHRRGSHRKVTLNGKQSVFPYHGSKEIGTGLVNKIKKDLDLK
Download Length: 183 bp
>T168641 NZ_CP076173:241541-241891 [Bacillus anthracis]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGTGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGTGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA
Antitoxin
Download Length: 140 a.a. Molecular weight: 15957.34 Da Isoelectric Point: 4.6983
>AT168641 WP_006250984.1 NZ_CP059323:c219064-218645 [Mannheimia haemolytica]
MLRYPVEITPDDNGTYLVTCPDIPEMASVGEDLEEALLEAQDGLATALEFYFDDRREIPMPSPIKEGQHTVNLTVLQSMK
VFLLNEMIKQGVRKAEMARRLDVHLPQIDRLLDFNHSTKVEFVEKAYGKLNQRFTILPH
MLRYPVEITPDDNGTYLVTCPDIPEMASVGEDLEEALLEAQDGLATALEFYFDDRREIPMPSPIKEGQHTVNLTVLQSMK
VFLLNEMIKQGVRKAEMARRLDVHLPQIDRLLDFNHSTKVEFVEKAYGKLNQRFTILPH
Download Length: 420 bp
>AT168641 NZ_CP076173:241249-241536 [Bacillus anthracis]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A378NFX7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A378NET2 |