Detailed information of TA system TA168639

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 5718544..5719114
• Replicon: chromosome
• Accession: NZ_CP059319
• Organism: Rhizorhabdus wittichii strain MPO218

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A975D2V1
• Locus tag: HRJ34_RS27310
• Protein ID: WP_029993579.1
• Coordinates: 5718830..5719114 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A975D344
• Locus tag: HRJ34_RS27305
• Protein ID: WP_011952066.1
• Coordinates: 5718544..5718849 (+)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRJ34_RS27280 (HRJ34_27275)	5714104..5714541	-	438	WP_208632978.1	EF-hand domain-containing protein	-
HRJ34_RS27285 (HRJ34_27280)	5714577..5715347	-	771	WP_226948981.1	hypothetical protein	-
HRJ34_RS27290 (HRJ34_27285)	5715259..5715696	-	438	WP_016747845.1	response regulator	-
HRJ34_RS27295 (HRJ34_27290)	5715811..5717211	-	1401	WP_011952068.1	pyruvate dehydrogenase complex E1 component subunit beta	-
HRJ34_RS27300 (HRJ34_27295)	5717211..5718218	-	1008	WP_226949221.1	pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha	-
HRJ34_RS27305 (HRJ34_27300)	5718544..5718849	+	306	WP_011952066.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HRJ34_RS27310 (HRJ34_27305)	5718830..5719114	+	285	WP_029993579.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
HRJ34_RS27315 (HRJ34_27310)	5719145..5719453	-	309	WP_011952065.1	septum formation initiator family protein	-
HRJ34_RS27320 (HRJ34_27315)	5719485..5720183	-	699	WP_208632980.1	uracil-DNA glycosylase	-
HRJ34_RS27325 (HRJ34_27320)	5720366..5720989	+	624	WP_016747848.1	hypothetical protein	-
HRJ34_RS27330 (HRJ34_27325)	5721001..5722461	+	1461	WP_208632981.1	hypothetical protein	-
HRJ34_RS27335 (HRJ34_27330)	5722483..5722959	+	477	WP_011952061.1	hypothetical protein	-
HRJ34_RS27340 (HRJ34_27335)	5722956..5723246	+	291	WP_208632982.1	hypothetical protein	-
HRJ34_RS27345 (HRJ34_27340)	5723246..5724076	+	831	WP_208632983.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-57)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10866.36 Da
• Isoelectric Point: 4.6761

>T168639 WP_029993579.1 NZ_CP059319:5718830-5719114 [Rhizorhabdus wittichii]
VASPTLEWSEAARKDLLSIVDFIADDNPDAALKLLDDIENKAEQLLHHPRLYEVGRVDGTREMLVRQNYIVVYAEDEQRV
LILRVLHGAQFWPR

Nucleotide

• Length: 285 bp

>T168639 NZ_CP076170:241541-241891 [Bacillus anthracis]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGTGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 10855.42 Da
• Isoelectric Point: 10.1685

>AT168639 WP_011952066.1 NZ_CP059319:5718544-5718849 [Rhizorhabdus wittichii]
MAGRTSMLHVRVDEELKARASQTLADVGLSVSDAVRILLARVAKEGGLPAGLTVDPETHDAWFRAKVREALDDGGPTRPQ
ARVMDEARALVVGKRRGKPDA

Nucleotide

• Length: 306 bp

>AT168639 NZ_CP076170:241249-241536 [Bacillus anthracis]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA