Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3230027..3230636 Replicon chromosome
Accession NZ_CP059319
Organism Rhizorhabdus wittichii strain MPO218

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HRJ34_RS15320 Protein ID WP_208631705.1
Coordinates 3230448..3230636 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HRJ34_RS15315 Protein ID WP_208631704.1
Coordinates 3230027..3230416 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRJ34_RS15290 (HRJ34_15285) 3225045..3226166 + 1122 WP_012049546.1 helix-turn-helix transcriptional regulator -
HRJ34_RS15295 (HRJ34_15290) 3226348..3227115 - 768 WP_029992994.1 SDR family oxidoreductase -
HRJ34_RS15300 (HRJ34_15295) 3227112..3228263 - 1152 WP_012049544.1 LLM class flavin-dependent oxidoreductase -
HRJ34_RS15305 (HRJ34_15300) 3228351..3229295 - 945 WP_208631702.1 site-specific DNA-methyltransferase -
HRJ34_RS15310 (HRJ34_15305) 3229292..3229930 - 639 WP_208631703.1 maleylacetoacetate isomerase -
HRJ34_RS15315 (HRJ34_15310) 3230027..3230416 - 390 WP_208631704.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HRJ34_RS15320 (HRJ34_15315) 3230448..3230636 - 189 WP_208631705.1 type II toxin-antitoxin system HicA family toxin Toxin
HRJ34_RS15325 (HRJ34_15320) 3230947..3231906 - 960 WP_208631706.1 site-specific integrase -
HRJ34_RS15330 (HRJ34_15325) 3231942..3232307 - 366 WP_208631707.1 helix-turn-helix domain-containing protein -
HRJ34_RS15335 (HRJ34_15330) 3232307..3233125 - 819 WP_208631708.1 hypothetical protein -
HRJ34_RS15340 (HRJ34_15335) 3233112..3233480 - 369 WP_208631709.1 hypothetical protein -
HRJ34_RS15345 (HRJ34_15340) 3233650..3233961 - 312 WP_208631710.1 hypothetical protein -
HRJ34_RS15350 (HRJ34_15345) 3233958..3234518 - 561 WP_208631711.1 hypothetical protein -
HRJ34_RS15355 (HRJ34_15350) 3234515..3234736 - 222 WP_208631712.1 hypothetical protein -
HRJ34_RS15360 (HRJ34_15355) 3234729..3235031 - 303 WP_208631713.1 MarR family transcriptional regulator -
HRJ34_RS15365 (HRJ34_15360) 3235024..3235161 - 138 WP_208631714.1 hypothetical protein -
HRJ34_RS15370 (HRJ34_15365) 3235158..3235364 - 207 WP_208631715.1 hypothetical protein -
HRJ34_RS15375 (HRJ34_15370) 3235364..3235636 - 273 WP_157783552.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3228351..3281512 53161


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-120)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6938.99 Da        Isoelectric Point: 11.2092

>T168638 WP_208631705.1 NZ_CP059319:c3230636-3230448 [Rhizorhabdus wittichii]
MRSADVIKKLEADGWREVRQSGSHKQFRHPTKPGTVTVPHPKKEMTTGTLKSIEKQSGVGLR

Download         Length: 189 bp

>T168638 NZ_CP076167:2317025-2317762 [Bacillus anthracis]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTTCTTGTTTTCTTTTACTGGAGAAATGA
AGAATTGTATGAGGAGAAGAAGCAACGAATTAGAAAGACTTGGTATGGGTTGTTTATAGTATCAGTCACCGTGTATTTCA
TGATAAAAGGAATCGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACGGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATCCGTTCTCAATTTAGTACGATTATTCCGTTAGA
GTACATTGAGCAATTGAATGAGCAGAGAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 14034.89 Da        Isoelectric Point: 4.6564

>AT168638 WP_208631704.1 NZ_CP059319:c3230416-3230027 [Rhizorhabdus wittichii]
MTTIFYPAIIERAPDGYGVFFPDLPGCTSGGRTVQEAARMAEEALDGHLLVTAQHGETLPEPSELDAVERDPEVDEVARI
LVRAQKPGRAIRINITMDEGLVARIDRASKNRSRFIADAARMALASTEA

Download         Length: 390 bp

>AT168638 NZ_CP076167:2317875-2318000 [Bacillus anthracis]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References