Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2611521..2612200 Replicon chromosome
Accession NZ_CP059319
Organism Rhizorhabdus wittichii strain MPO218

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HRJ34_RS12300 Protein ID WP_208634226.1
Coordinates 2611521..2611949 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A975D714
Locus tag HRJ34_RS12305 Protein ID WP_016746771.1
Coordinates 2611946..2612200 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRJ34_RS12265 (HRJ34_12260) 2607503..2608540 - 1038 WP_208634225.1 GTPase ObgE -
HRJ34_RS12270 (HRJ34_12265) 2608593..2609162 - 570 WP_037519979.1 TetR/AcrR family transcriptional regulator -
HRJ34_RS12275 (HRJ34_12270) 2609290..2609862 - 573 WP_012050077.1 GNAT family N-acetyltransferase -
HRJ34_RS12280 (HRJ34_12275) 2610042..2610311 - 270 WP_012050076.1 50S ribosomal protein L27 -
HRJ34_RS12285 (HRJ34_12280) 2610338..2610700 - 363 WP_012050075.1 50S ribosomal protein L21 -
HRJ34_RS12290 (HRJ34_12285) 2610897..2611268 - 372 WP_029548942.1 heat shock protein HspQ -
HRJ34_RS12300 (HRJ34_12295) 2611521..2611949 - 429 WP_208634226.1 type II toxin-antitoxin system VapC family toxin Toxin
HRJ34_RS12305 (HRJ34_12300) 2611946..2612200 - 255 WP_016746771.1 plasmid stabilization protein Antitoxin
HRJ34_RS12310 (HRJ34_12305) 2612275..2613258 - 984 WP_029548941.1 AraC family transcriptional regulator -
HRJ34_RS12315 (HRJ34_12310) 2613398..2614189 - 792 WP_208634227.1 SDR family oxidoreductase -
HRJ34_RS12320 (HRJ34_12315) 2614176..2615693 - 1518 WP_208634228.1 NAD(P)/FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15303.49 Da        Isoelectric Point: 4.7290

>T168637 WP_208634226.1 NZ_CP059319:c2611949-2611521 [Rhizorhabdus wittichii]
MIVLDTNVVSEAMKPEPNPDVCAWLDEQAAETLYLSSVTIAELLFGIGALPDGRRKDRLAVALDGLLELFDGRILPFDMA
AARHYADRAVRARSAGKGFPTPDGYIAAIAVSRSFVVATRDASAFDAAGIAVIDPWKADRRQ

Download         Length: 429 bp

>T168637 NZ_CP076167:241540-241890 [Bacillus anthracis]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGTGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9258.43 Da        Isoelectric Point: 9.0310

>AT168637 WP_016746771.1 NZ_CP059319:c2612200-2611946 [Rhizorhabdus wittichii]
MPAVTIRNLSEEAHRALKIRAAHHGRSTEAEMRDILEGAVRPANRVRIGSALSRLSRDAGLTNADFEALDQARDRKPAEP
LGFE

Download         Length: 255 bp

>AT168637 NZ_CP076167:241248-241535 [Bacillus anthracis]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References