Detailed information of TA system TA168636

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 988268..989037
• Replicon: chromosome
• Accession: NZ_CP059319
• Organism: Rhizorhabdus wittichii strain MPO218

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: A0A126RRI7
• Locus tag: HRJ34_RS04850
• Protein ID: WP_030090520.1
• Coordinates: 988268..988795 (-)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: -
• Locus tag: HRJ34_RS04855
• Protein ID: WP_021688187.1
• Coordinates: 988792..989037 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRJ34_RS04820 (HRJ34_04825)	983315..983794	-	480	WP_021688180.1	hypothetical protein	-
HRJ34_RS04825 (HRJ34_04830)	983800..984555	-	756	WP_021688181.1	hypothetical protein	-
HRJ34_RS04830 (HRJ34_04835)	984599..985060	-	462	WP_021688182.1	hypothetical protein	-
HRJ34_RS04835 (HRJ34_04840)	985072..985719	-	648	WP_021688183.1	hypothetical protein	-
HRJ34_RS04840 (HRJ34_04845)	985943..987163	-	1221	WP_021688184.1	hypothetical protein	-
HRJ34_RS04845 (HRJ34_04850)	987591..987932	-	342	WP_021688185.1	sigma factor-like helix-turn-helix DNA-binding protein	-
HRJ34_RS04850 (HRJ34_04855)	988268..988795	-	528	WP_030090520.1	hypothetical protein	Toxin
HRJ34_RS04855 (HRJ34_04860)	988792..989037	-	246	WP_021688187.1	DUF1778 domain-containing protein	Antitoxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	961055..1003317	42262

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (2-77)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 19149.84 Da
• Isoelectric Point: 7.9468

>T168636 WP_030090520.1 NZ_CP059319:c988795-988268 [Rhizorhabdus wittichii]
MRLPSWHEDAIAKAHDRASFDCGDNDLNIFLRRYARQSHELGGAKTFLAVDDTDNKTILGFYSIAPGSMDHADTPELARR
GLARHEVPGFRLARLATDIRVQGNGLGGQLLGAIGRRCIRVAAEVGGVMLIIDAKNERAAAWYASYGAITLHDKPLTLIL
PFATLERELRSAGQL

Nucleotide

• Length: 528 bp

>T168636 NZ_CP076164:2316957-2317694 [Bacillus anthracis]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTTCTTGTTTTCTTTTACTGGAGAAATGA
AGAATTGTATGAGGAGAAGAAGCAACGAATTAGAAAGACTTGGTATGGGTTGTTTATAGTATCAGTCACCGTGTATTTCA
TGATAAAAGGAATCGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACGGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATCCGTTCTCAATTTAGTACGATTATTCCGTTAGA
GTACATTGAGCAATTGAATGAGCAGAGAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8832.28 Da
• Isoelectric Point: 8.8557

>AT168636 WP_021688187.1 NZ_CP059319:c989037-988792 [Rhizorhabdus wittichii]
MSLRIRPEQKALLARAAALRHTDLTTFVTGSALREAESVIEEAERTKLSERDSLLVLDLLENPPPANAKLRAAIAAMPKL
A

Nucleotide

• Length: 246 bp

>AT168636 NZ_CP076164:2317807-2317932 [Bacillus anthracis]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATGA

Structures

Toxin

• AlphaFold DB: A0A126RRI7