Detailed information of TA system TA168611

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4888625..4890306
• Replicon: chromosome
• Accession: NZ_CP059312
• Organism: Klebsiella pneumoniae strain Kp46596

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A6TH06
• Locus tag: H1D28_RS26530
• Protein ID: WP_015959269.1
• Coordinates: 4888625..4889500 (-)
• Length: 292 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: H1D28_RS26535
• Protein ID: WP_004177809.1
• Coordinates: 4889548..4890306 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H1D28_RS26510	4883931..4885451	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
H1D28_RS26515	4885448..4886446	+	999	WP_002885172.1	ribose ABC transporter permease	-
H1D28_RS26520	4886477..4887418	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
H1D28_RS26525	4887493..4888500	+	1008	WP_015959270.1	carbohydrate kinase family protein	-
H1D28_RS26530	4888625..4889500	-	876	WP_015959269.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
H1D28_RS26535	4889548..4890306	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
H1D28_RS26540	4890392..4891120	-	729	WP_032413197.1	response regulator transcription factor	-
H1D28_RS26545	4891393..4893540	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
H1D28_RS26550	4893537..4893680	-	144	WP_162897205.1	hypothetical protein	-
H1D28_RS26555	4894118..4894804	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (7-264)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 292 a.a.
• Molecular weight: 32990.17 Da
• Isoelectric Point: 5.4637

>T168611 WP_015959269.1 NZ_CP059312:c4889500-4888625 [Klebsiella pneumoniae]
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMSAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKSCITQQDVDFLLSFK
RGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 876 bp

>T168611 NZ_CP076136:1251062-1251463 [Bradyrhizobium sediminis]
ATGATCGTGGTCGACAGTTCGGCCGTCATCGCCATCTTCCGTCAGGAGGAGGATGCAGGGGATTATGCCCGACGCATCGC
TGCCGACGACGATCCGGTGATGTCTGCCGCCAATCTGGTAGAGACTTCGATTGTGCTGCGTGGATTGAAAAAGATTGCGC
CGGAAAAGGCCGAGCGATGGCTTGACGATTTCATGAAGGCGGCCGGCATCCGGATAGAGCCGGTGACGCCGGATCAGGCG
CAAGCGGCTCGCTCGGCTCATCGGCGATTCGGGAAGGGGACCGGGCATAGCGCCGCGCTGAACTATGGCGACTGCTTTTC
CTACGCACTGGCAAAGCTCATGGACGCGCCGTTACTTTGCAAAGGCAACGATTTTCCATCGACCGACATCGGTATTGCGT
AG

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT168611 WP_004177809.1 NZ_CP059312:c4890306-4889548 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT168611 NZ_CP076136:1250814-1251065 [Bradyrhizobium sediminis]
ATGCATCTGAACATCAAGAATGATGAGGCGCACAAGCTTGCATCCGAGCTTGCGCAACTGACCGGCGAAAGCCTGACATC
GGCAGTCACACTGGCCCTGCGGGAGCGCCTCGCGAGGGAGCGCCGCCGTTCCCGAGCCGACCGCGTCGCCGCCAGCCTGA
TGAAGATTGGCAGCGAGTACGCCGCGCTTGCCGACACCGGCCGCAGCCCGGACGAAATCCTCGGATATGACGAGCACGGA
TTGCCGACATGA

Structures

Toxin

• AlphaFold DB: A6TH06

Antitoxin

• AlphaFold DB: A6TH05