168608

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3991089..3991708 Replicon chromosome
Accession NZ_CP059312
Organism Klebsiella pneumoniae strain Kp46596

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag H1D28_RS22285 Protein ID WP_002892050.1
Coordinates 3991490..3991708 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag H1D28_RS22280 Protein ID WP_002892066.1
Coordinates 3991089..3991463 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D28_RS22270 3986241..3987434 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
H1D28_RS22275 3987457..3990603 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
H1D28_RS22280 3991089..3991463 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
H1D28_RS22285 3991490..3991708 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
H1D28_RS22290 3991871..3992437 + 567 WP_002892030.1 maltose O-acetyltransferase -
H1D28_RS22295 3992409..3992549 - 141 WP_004147370.1 hypothetical protein -
H1D28_RS22300 3992570..3993040 + 471 WP_020802585.1 YlaC family protein -
H1D28_RS22305 3993015..3994466 - 1452 WP_004183206.1 PLP-dependent aminotransferase family protein -
H1D28_RS22310 3994567..3995265 + 699 WP_023287311.1 GNAT family N-acetyltransferase -
H1D28_RS22315 3995262..3995402 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
H1D28_RS22320 3995402..3995665 - 264 WP_032432663.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T168608 WP_002892050.1 NZ_CP059312:3991490-3991708 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T168608 NZ_CP076135:2505289-2505477 [Bradyrhizobium sediminis]
ATGAAAAGTCGGGAAATTATCTCGGCCCTTCAAAGGGATGGATGGCATGAGGTCGCCCGGAAGGGAAGCCACGTTCAATT
CAAGCACCCTCGAAAAAAGGGCCGCGTAACCGTTCCGCACCCTGAACGAGATATCCCGGTCGGGACACTCAAAAGCATCG
AAAAGCAATCGGGTCTTAAACTGAGGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT168608 WP_002892066.1 NZ_CP059312:3991089-3991463 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT168608 NZ_CP076135:2505483-2505881 [Bradyrhizobium sediminis]
ATGGGTCAGTATATTGGTCTTATCCATAAAGAAGCAGACAGCCACTTTGGCGTATCGTTTCCAGACTTCCCGGGTGTTGC
TACCGCCGGGACCACACTGGATGACGCCCGAGCTATGGCAGAAGAAGCCCTAGCCTTTCATATTGAAGGTTTGGTCGAGG
ATGGAGAGGCCATCCCCGAACCCTCCAGCCTTGAAGACGTTATGGCCGATCCGGACAATCGATCCGGCGTCGCAATCCTG
GTTGCCGCGAAGACTGAGGCGCCCAAGGTTATCCGGGTAAACGTGACCTTGCCCGGTGATATCTTGGAGCAAATCGACAA
ATATGCAGAGGCGCACGGGCTTTCTAGATCTGGCTTCCTAACTCAGGCCGCCAAAAAAGCGATGCTTGAGGCCGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References