Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2679556..2681144 Replicon chromosome
Accession NZ_CP059312
Organism Klebsiella pneumoniae strain Kp46596

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag H1D28_RS15880 Protein ID WP_002904792.1
Coordinates 2679556..2680878 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag H1D28_RS15885 Protein ID WP_002904790.1
Coordinates 2680878..2681144 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D28_RS15865 2674612..2677113 + 2502 WP_032433099.1 fimbrial biogenesis outer membrane usher protein -
H1D28_RS15870 2677101..2678105 + 1005 WP_032433097.1 type 1 fimbrial protein -
H1D28_RS15875 2678247..2679539 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
H1D28_RS15880 2679556..2680878 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
H1D28_RS15885 2680878..2681144 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
H1D28_RS15890 2681530..2681856 - 327 WP_002904788.1 hydroxyisourate hydrolase -
H1D28_RS15895 2681853..2682353 - 501 WP_032433095.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
H1D28_RS15900 2682331..2683710 - 1380 WP_032433093.1 purine permease -
H1D28_RS15905 2684056..2685210 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
H1D28_RS15910 2685191..2686114 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T168607 WP_002904792.1 NZ_CP059312:c2680878-2679556 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T168607 NZ_CP076134:5078914-5079210 [Bradyrhizobium sediminis]
ATGATCGTTAGCTTCCGGGATGACTGGTTTCGGGAGTTCTTCGTCAACGACGTCAGGTCGAAGAAAATCCCGTCCGATCT
GGAAGATCGCCTGTTCCGCAAGATCCAGATGATCGACGATGCGACAACGGACCGCGATCTGAGATCGCCGCCCAGCAACC
ATTTCGAGAAGCTGCGGGGCAATCTCGAAGGCCTCCACTCGATCCGCGTCAATAAGCGATGGCGGCTGGTGTTTCGATGG
GACAGCAGTCGGGGCGAGGCGAAAGATTTATATCTGGACGACCACAGCTACGATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT168607 WP_002904790.1 NZ_CP059312:c2681144-2680878 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT168607 NZ_CP076134:5079219-5079527 [Bradyrhizobium sediminis]
ATGTTGATGACGAAACGCAAGCCGGCGACAACAGGCGAAATCCTGGTCGAGGAATTCATGAAGCCGATCGGCCTGACGCA
AGGCGCGCTGGCCGAAGCCATGGGCGTGCAGCGCAAGCACGTCAATGAGCTGTGCAACGATCGCCGCAACGTGACCGCGG
CGACCGCGCTGATTCTCGCCCGCGTGTTCGGCAACAGCCCGGATTTCTGGCTCAATGTGCAGCGGCGGACCGATTTGTGG
GAAGCGATGCATTCGCCGCGGGAGCGCAAACGTATTGAACGGGCGCGACCGTTGACGGATGCGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References