Detailed information of TA system TA168607

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2679556..2681144
• Replicon: chromosome
• Accession: NZ_CP059312
• Organism: Klebsiella pneumoniae strain Kp46596

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: W8UI36
• Locus tag: H1D28_RS15880
• Protein ID: WP_002904792.1
• Coordinates: 2679556..2680878 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: H1D28_RS15885
• Protein ID: WP_002904790.1
• Coordinates: 2680878..2681144 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H1D28_RS15865	2674612..2677113	+	2502	WP_032433099.1	fimbrial biogenesis outer membrane usher protein	-
H1D28_RS15870	2677101..2678105	+	1005	WP_032433097.1	type 1 fimbrial protein	-
H1D28_RS15875	2678247..2679539	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
H1D28_RS15880	2679556..2680878	-	1323	WP_002904792.1	type II toxin-antitoxin system HipA family toxin	Toxin
H1D28_RS15885	2680878..2681144	-	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
H1D28_RS15890	2681530..2681856	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
H1D28_RS15895	2681853..2682353	-	501	WP_032433095.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
H1D28_RS15900	2682331..2683710	-	1380	WP_032433093.1	purine permease	-
H1D28_RS15905	2684056..2685210	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
H1D28_RS15910	2685191..2686114	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49171.46 Da
• Isoelectric Point: 7.5357

>T168607 WP_002904792.1 NZ_CP059312:c2680878-2679556 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T168607 NZ_CP076134:5078914-5079210 [Bradyrhizobium sediminis]
ATGATCGTTAGCTTCCGGGATGACTGGTTTCGGGAGTTCTTCGTCAACGACGTCAGGTCGAAGAAAATCCCGTCCGATCT
GGAAGATCGCCTGTTCCGCAAGATCCAGATGATCGACGATGCGACAACGGACCGCGATCTGAGATCGCCGCCCAGCAACC
ATTTCGAGAAGCTGCGGGGCAATCTCGAAGGCCTCCACTCGATCCGCGTCAATAAGCGATGGCGGCTGGTGTTTCGATGG
GACAGCAGTCGGGGCGAGGCGAAAGATTTATATCTGGACGACCACAGCTACGATTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT168607 WP_002904790.1 NZ_CP059312:c2681144-2680878 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT168607 NZ_CP076134:5079219-5079527 [Bradyrhizobium sediminis]
ATGTTGATGACGAAACGCAAGCCGGCGACAACAGGCGAAATCCTGGTCGAGGAATTCATGAAGCCGATCGGCCTGACGCA
AGGCGCGCTGGCCGAAGCCATGGGCGTGCAGCGCAAGCACGTCAATGAGCTGTGCAACGATCGCCGCAACGTGACCGCGG
CGACCGCGCTGATTCTCGCCCGCGTGTTCGGCAACAGCCCGGATTTCTGGCTCAATGTGCAGCGGCGGACCGATTTGTGG
GAAGCGATGCATTCGCCGCGGGAGCGCAAACGTATTGAACGGGCGCGACCGTTGACGGATGCGGCGTGA

Structures

Toxin

• AlphaFold DB: A0A0E1CEC8

Antitoxin

• AlphaFold DB: A0A0H3GXD8