Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 209481..210003 Replicon plasmid pKp46596-1
Accession NZ_CP059311
Organism Klebsiella pneumoniae strain Kp46596

Toxin (Protein)


Gene name stbE Uniprot ID A0A0C7KG00
Locus tag H1D28_RS02320 Protein ID WP_038991638.1
Coordinates 209719..210003 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag H1D28_RS02315 Protein ID WP_004181777.1
Coordinates 209481..209729 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D28_RS02295 204690..205511 - 822 WP_004181772.1 hypothetical protein -
H1D28_RS02300 205573..205926 - 354 WP_004181774.1 hypothetical protein -
H1D28_RS02305 206071..207057 - 987 WP_040120328.1 hypothetical protein -
H1D28_RS02310 207391..209190 - 1800 WP_038991636.1 ATP-dependent helicase -
H1D28_RS02315 209481..209729 + 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
H1D28_RS02320 209719..210003 + 285 WP_038991638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H1D28_RS02325 210020..210121 - 102 Protein_227 IS200/IS605 family transposase -
H1D28_RS02330 210157..211383 + 1227 WP_040120327.1 transposase -
H1D28_RS02335 211655..211879 - 225 Protein_229 transposase -
H1D28_RS02340 211958..212386 - 429 WP_077256229.1 IS200/IS605 family transposase -
H1D28_RS02345 212422..213609 + 1188 WP_040120325.1 transposase -
H1D28_RS02350 213708..214803 - 1096 Protein_232 conjugal transfer protein TraG N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid qnrB1 / blaNDM-1 / blaCTX-M-15 / blaOXA-1 / aac(6')-Ib-cr / catA1 / mph(E) / msr(E) / armA / sul1 / qacE / aadA2 / dfrA12 htpB 1..286241 286241


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10993.73 Da        Isoelectric Point: 10.6516

>T168593 WP_038991638.1 NZ_CP059311:209719-210003 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYHLTKHRN

Download         Length: 285 bp

>T168593 NZ_CP076123:3280348-3280725 [Escherichia coli]
ATGAACACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTACGAACTGACCAGCCAGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAATGGTAAATAACATTACCCAGGGTAAGCATCCGGAGGCGCAACAATGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT168593 WP_004181777.1 NZ_CP059311:209481-209729 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp

>AT168593 NZ_CP076123:3279890-3280258 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACGACAATCACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGAAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAACGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7KG00

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References