Detailed information of TA system TA168590

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 5209..5831
• Replicon: plasmid pAC1633-2
• Accession: NZ_CP059303
• Organism: Acinetobacter baumannii strain AC1633

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0A8TLU5
• Locus tag: H0529_RS21955
• Protein ID: WP_042088825.1
• Coordinates: 5209..5604 (-)
• Length: 132 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: N9QGM1
• Locus tag: H0529_RS21960
• Protein ID: WP_004282079.1
• Coordinates: 5601..5831 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0529_RS21930	237..1424	-	1188	WP_004856455.1	tetracycline efflux MFS transporter Tet(39)	-
H0529_RS21935	1490..2131	+	642	WP_004787586.1	TetR/AcrR family transcriptional regulator C-terminal domain-containing protein	-
H0529_RS21940	2720..3430	+	711	WP_114213634.1	toll/interleukin-1 receptor domain-containing protein	-
H0529_RS21945	3584..3985	+	402	WP_114213635.1	hypothetical protein	-
H0529_RS21950	3994..4806	+	813	WP_114213636.1	hypothetical protein	-
H0529_RS21955	5209..5604	-	396	WP_042088825.1	type II toxin-antitoxin system VapC family toxin	Toxin
H0529_RS21960	5601..5831	-	231	WP_004282079.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
H0529_RS21965	6454..6867	+	414	WP_086231618.1	hypothetical protein	-
H0529_RS21970	6870..7184	+	315	WP_000723215.1	hypothetical protein	-
H0529_RS21975	7221..7442	-	222	WP_192596778.1	hypothetical protein	-
H0529_RS21980	7439..7795	-	357	WP_192596779.1	hypothetical protein	-
H0529_RS21985	7835..8725	-	891	WP_192596780.1	MobA/MobL family protein	-
H0529_RS21990	8937..9659	+	723	WP_192596781.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	tet(39)	-	1..12651	12651

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-124)

Antitoxin

• SpoVT-AbrB domain (7-39)

Sequences

Toxin

Protein

• Length: 132 a.a.
• Molecular weight: 14906.20 Da
• Isoelectric Point: 6.7181

>T168590 WP_042088825.1 NZ_CP059303:c5604-5209 [Acinetobacter baumannii]
MIYLLDTNICIYVINNKPQHVFERFKQYQLGQLAISSITASELAFGVEKSGSERNKQALNKFLSPLEILPYDEQAIWHYA
KLRQNLQSTGKPIGSLDMLIAAHALALDVVLVTNNTKEFERIDGLKLENWV

Nucleotide

• Length: 396 bp

>T168590 NZ_CP076123:c2888877-2888500 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCTGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AAGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCCCTGGTGCGTACCGACCAGCCGGGATTC
AGCCCCTGTACCCGCTCTCAGTTAATCAACAGTATCGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCGGGGTAAGCATCCGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8738.96 Da
• Isoelectric Point: 4.7708

>AT168590 WP_004282079.1 NZ_CP059303:c5831-5601 [Acinetobacter baumannii]
MEIAKVFQTGRSQAVRLPKAFRFNGTEVAIKSFGRGVLLMPIDNPWDVMLEAVNEFESGFQLERADQGEQFREEFK

Nucleotide

• Length: 231 bp

>AT168590 NZ_CP076123:c2889335-2888967 [Escherichia coli]
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Structures

Toxin

• AlphaFold DB: A0A0A8TLU5

Antitoxin

• AlphaFold DB: N9QGM1