168587

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 155224..155812 Replicon plasmid pAC1633-1
Accession NZ_CP059301
Organism Acinetobacter baumannii strain AC1633

Toxin (Protein)


Gene name relE Uniprot ID N9CKJ9
Locus tag H0529_RS21785 Protein ID WP_004647749.1
Coordinates 155224..155520 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag H0529_RS21790 Protein ID WP_004969304.1
Coordinates 155522..155812 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0529_RS21755 150274..151077 + 804 WP_001082319.1 aminoglycoside O-phosphotransferase APH(3'')-Ib -
H0529_RS21760 151077..151913 + 837 WP_000480968.1 aminoglycoside O-phosphotransferase APH(6)-Id -
H0529_RS21765 152055..152276 + 222 Protein_144 hypothetical protein -
H0529_RS21770 152327..153031 - 705 WP_001067784.1 IS6-like element IS1006 family transposase -
H0529_RS21775 153094..153486 + 393 Protein_146 recombinase family protein -
H0529_RS21780 153707..154780 + 1074 WP_043041639.1 hypothetical protein -
H0529_RS21785 155224..155520 + 297 WP_004647749.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H0529_RS21790 155522..155812 + 291 WP_004969304.1 putative addiction module antidote protein Antitoxin
H0529_RS21795 155923..157377 - 1455 WP_026438532.1 SulP family inorganic anion transporter -
H0529_RS21800 157627..157836 - 210 WP_004976362.1 hypothetical protein -
H0529_RS21805 158106..158474 - 369 Protein_152 IS1-like element ISAba3 family transposase -
H0529_RS21810 158555..159397 + 843 WP_002002480.1 carbapenem-hydrolyzing class D beta-lactamase OXA-58 -
H0529_RS21815 159451..160479 + 1029 WP_081106503.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aac(3)-IId / sul2 / blaNDM-1 / aph(3'')-Ib / aph(6)-Id / blaOXA-58 / msr(E) / mph(E) - 1..174292 174292
- inside IScluster/Tn aph(3'')-Ib / aph(6)-Id / blaOXA-58 / msr(E) / mph(E) - 149082..170063 20981


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-92)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11584.25 Da        Isoelectric Point: 5.8801

>T168587 WP_004647749.1 NZ_CP059301:155224-155520 [Acinetobacter baumannii]
MIEIKRLPEFDEWLDGIKDNMTRIRLNRRLDKVQRGNWGDIKPLQDGVWEMREFFGSGWRMYYIQHGDVVIVMLGGGDKS
TQQQDIDRAVKLSKTLED

Download         Length: 297 bp

>T168587 NZ_CP076123:1947495-1947602 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10524.19 Da        Isoelectric Point: 5.1133

>AT168587 WP_004969304.1 NZ_CP059301:155522-155812 [Acinetobacter baumannii]
MVKVADLPSFDMAESLKTEEDIVMYLNMVLEENDPAELAHALGVIAKARGMTQIAKEAGIGREALYKALRQDSAPRFDTI
NRVVNALGLKLTVQHA

Download         Length: 291 bp

>AT168587 NZ_CP076123:c1947442-1947381 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References