Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3837023..3837676 Replicon chromosome
Accession NZ_CP059300
Organism Acinetobacter baumannii strain AC1633

Toxin (Protein)


Gene name cptA Uniprot ID A0A3R9G864
Locus tag H0529_RS18605 Protein ID WP_000607075.1
Coordinates 3837287..3837676 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag H0529_RS18600 Protein ID WP_001288210.1
Coordinates 3837023..3837280 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0529_RS18580 3832539..3833546 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
H0529_RS18585 3833565..3833942 + 378 WP_001216380.1 50S ribosomal protein L17 -
H0529_RS18590 3834124..3835614 + 1491 WP_031966421.1 NAD(P)/FAD-dependent oxidoreductase -
H0529_RS18595 3835663..3836835 - 1173 WP_032028213.1 acyl-CoA dehydrogenase family protein -
H0529_RS18600 3837023..3837280 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
H0529_RS18605 3837287..3837676 + 390 WP_000607075.1 membrane protein Toxin
H0529_RS18610 3838446..3839531 + 1086 WP_000049106.1 hypothetical protein -
H0529_RS18615 3839609..3840175 + 567 WP_000651536.1 rhombosortase -
H0529_RS18620 3840363..3842558 + 2196 WP_001158905.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15649.94 Da        Isoelectric Point: 10.3890

>T168586 WP_000607075.1 NZ_CP059300:3837287-3837676 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKVIDYQIFIVIYFEGHKTLTSIIWFDQMSLVEWKKLKTLEKLY

Download         Length: 390 bp

>T168586 NZ_CP076123:1717014-1717292 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT168586 WP_001288210.1 NZ_CP059300:3837023-3837280 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT168586 NZ_CP076123:1717292-1717576 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCAGAA
AAAACAGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R9G864

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References