Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 4098686..4099271 Replicon chromosome
Accession NZ_CP059298
Organism Providencia rettgeri strain P01

Toxin (Protein)


Gene name relE Uniprot ID D4C3N9
Locus tag H0904_RS18980 Protein ID WP_004905874.1
Coordinates 4098686..4099003 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4C3P0
Locus tag H0904_RS18985 Protein ID WP_004905876.1
Coordinates 4098984..4099271 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0904_RS18950 4094389..4094640 - 252 WP_094961642.1 DUF1471 domain-containing protein -
H0904_RS18955 4094911..4095249 + 339 WP_004905864.1 GIY-YIG nuclease family protein -
H0904_RS18960 4095222..4095725 - 504 WP_112308100.1 N-acetyltransferase -
H0904_RS18965 4095719..4096243 - 525 WP_112308101.1 SCP2 domain-containing protein -
H0904_RS18970 4096758..4097753 + 996 WP_094961644.1 U32 family peptidase -
H0904_RS18975 4097771..4098646 + 876 WP_112308102.1 U32 family peptidase -
H0904_RS18980 4098686..4099003 - 318 WP_004905874.1 type II toxin-antitoxin system YafQ family toxin Toxin
H0904_RS18985 4098984..4099271 - 288 WP_004905876.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
H0904_RS18990 4099402..4100556 - 1155 WP_004905877.1 ABC transporter permease -
H0904_RS18995 4100556..4101701 - 1146 WP_004905879.1 ABC transporter permease -
H0904_RS19000 4101713..4102684 - 972 WP_004905881.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(14-105)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(10-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12205.96 Da        Isoelectric Point: 9.7799

>T168584 WP_004905874.1 NZ_CP059298:c4099003-4098686 [Providencia rettgeri]
MTQKPSNKRAKQPRQVAYTPTFKKSWERYNRAGRRDMNAAVLVMEILFSQKIIPKEYLDHELEGHEWQGARELHIGGDFL
LVYRLSDKGNLITFVDIGSHSELFG

Download         Length: 318 bp

>T168584 NZ_CP076123:1362401-1362503 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10763.44 Da        Isoelectric Point: 5.8809

>AT168584 WP_004905876.1 NZ_CP059298:c4099271-4098984 [Providencia rettgeri]
MSTLLKTTDVRSRIDEQLKAEATSVLQDCGLTISAAIRLFLEQVVQEQRVPFEIKRKQPSLKTTLALKEAKAIEQHYDSI
NEMMVELSKVDSEAK

Download         Length: 288 bp

>AT168584 NZ_CP076123:c1362541-1362273 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D4C3N9

Antitoxin

Source ID Structure
AlphaFold DB A0A345M0A6

References