Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2969976..2970624 Replicon chromosome
Accession NZ_CP059298
Organism Providencia rettgeri strain P01

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag H0904_RS13665 Protein ID WP_094961724.1
Coordinates 2969976..2970161 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag H0904_RS13670 Protein ID WP_181489706.1
Coordinates 2970211..2970624 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0904_RS13645 2965850..2966938 - 1089 WP_004264880.1 sulfate/thiosulfate ABC transporter ATP-binding protein CysA -
H0904_RS13650 2966941..2967801 - 861 WP_004264881.1 sulfate/thiosulfate ABC transporter permease CysW -
H0904_RS13655 2967801..2968631 - 831 WP_004264883.1 sulfate/thiosulfate ABC transporter permease CysT -
H0904_RS13660 2968631..2969653 - 1023 WP_094961725.1 sulfate ABC transporter substrate-binding protein -
H0904_RS13665 2969976..2970161 + 186 WP_094961724.1 type II toxin-antitoxin system HicA family toxin Toxin
H0904_RS13670 2970211..2970624 + 414 WP_181489706.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H0904_RS13675 2970690..2971589 - 900 WP_094961722.1 Dyp-type peroxidase -
H0904_RS13680 2971832..2972437 - 606 WP_050763802.1 RpoE-regulated lipoprotein -
H0904_RS13685 2972529..2972960 - 432 WP_181488162.1 GNAT family acetyltransferase -
H0904_RS13690 2973097..2974014 + 918 WP_181488164.1 oxygen-dependent coproporphyrinogen oxidase -
H0904_RS13695 2974173..2975309 + 1137 WP_168697634.1 M4 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6992.20 Da        Isoelectric Point: 11.0146

>T168582 WP_094961724.1 NZ_CP059298:2969976-2970161 [Providencia rettgeri]
VQSSELINILQKNGWKLERIKGSHHQFSHPHFSIVITVPHPQKDLKIGTLNHILKAAKLKH

Download         Length: 186 bp

>T168582 NZ_CP076123:1063543-1063797 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15361.32 Da        Isoelectric Point: 4.5725

>AT168582 WP_181489706.1 NZ_CP059298:2970211-2970624 [Providencia rettgeri]
MLYTAFIEIDDDGSASGWFPDIEGCTFAGSNIEEAYAEAKSAIDAHFELLSEKGFEIPLSKSQQALLNPIQPEYAHGIWL
FVDVDMDKYDGRTERINITLPHRLLHRIDALVKVNPEYGSRSGFIAVAARKELKKTD

Download         Length: 414 bp

>AT168582 NZ_CP076123:1063295-1063546 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References