Detailed information of TA system TA168581

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 2341885..2342801
• Replicon: chromosome
• Accession: NZ_CP059298
• Organism: Providencia rettgeri strain P01

Toxin (Protein)

• Gene name: -
• Uniprot ID: D4BTW9
• Locus tag: H0904_RS10775
• Protein ID: WP_004254505.1
• Coordinates: 2341885..2342343 (-)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: H0904_RS10780
• Protein ID: WP_181487862.1
• Coordinates: 2342340..2342801 (-)
• Length: 154 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0904_RS10750	2337422..2338888	+	1467	WP_112307052.1	AMP nucleosidase	-
H0904_RS10755	2338869..2339432	+	564	WP_004254518.1	GNAT family N-acetyltransferase	-
H0904_RS10760	2339463..2339883	+	421	Protein_2099	helix-turn-helix domain-containing protein	-
H0904_RS10765	2339989..2340948	+	960	WP_094960599.1	acetyl-CoA carboxylase carboxyl transferase subunit alpha	-
H0904_RS10770	2340994..2341884	+	891	WP_094960598.1	LysR family transcriptional regulator	-
H0904_RS10775	2341885..2342343	-	459	WP_004254505.1	RES domain-containing protein	Toxin
H0904_RS10780	2342340..2342801	-	462	WP_181487862.1	DUF2384 domain-containing protein	Antitoxin
H0904_RS10785	2342890..2343357	-	468	WP_036957750.1	DUF1456 family protein	-
H0904_RS10790	2343545..2343859	-	315	WP_094960595.1	AzlD domain-containing protein	-
H0904_RS10795	2343856..2344557	-	702	WP_004254495.1	AzlC family ABC transporter permease	-
H0904_RS10800	2345028..2345669	+	642	WP_004254492.1	leucine efflux protein LeuE	-
H0904_RS10805	2345958..2346494	+	537	WP_181487864.1	NUDIX domain-containing protein	-
H0904_RS10810	2346524..2347138	-	615	WP_004254484.1	LysE family translocator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-145)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (38-95)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17088.65 Da
• Isoelectric Point: 6.2048

>T168581 WP_004254505.1 NZ_CP059298:c2342343-2341885 [Providencia rettgeri]
MILYRLVKSNFAHDAWSGQGAMLYGGRWNHKGTPAVYTSTSISLATLEILVHINQDILLSQFSLLSIDINDKYVMKLSLD
HLPTDWQQDPAPTSTMDIGTIWLNNQDSLALLIPSCIVPYEYNAIINPLHPQFQKALHTVKPLDFSVDPRLA

Nucleotide

• Length: 459 bp

>T168581 NZ_CP076123:1063295-1063546 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 154 a.a.
• Molecular weight: 17086.58 Da
• Isoelectric Point: 9.9140

>AT168581 WP_181487862.1 NZ_CP059298:c2342801-2342340 [Providencia rettgeri]
MRNYIPTPPLQPTASSFKPLWRHVGLPAERGIELTHFLRQGLSVSVLDNIQEWSGMSKTELLRISGINERNIARRKNAGQ
PLNADESERIARLVRVFDAAVRLFNGDKHAASDWLNHPVKGLGHLRPIELIATESGAIEVIDLIGRIEHGVFS

Nucleotide

• Length: 462 bp

>AT168581 NZ_CP076123:1063543-1063797 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Toxin

• AlphaFold DB: D4BTW9