Detailed information of TA system TA168580

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 1828868..1829403
• Replicon: chromosome
• Accession: NZ_CP059298
• Organism: Providencia rettgeri strain P01

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: H0904_RS08270
• Protein ID: WP_144141264.1
• Coordinates: 1828868..1829176 (-)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: D4BV21
• Locus tag: H0904_RS08275
• Protein ID: WP_004255691.1
• Coordinates: 1829176..1829403 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0904_RS08240	1824848..1825684	+	837	WP_094961163.1	chemotaxis protein-glutamate O-methyltransferase	-
H0904_RS08245	1825684..1826751	+	1068	WP_094961164.1	chemotaxis response regulator protein-glutamate methylesterase	-
H0904_RS08250	1826793..1827185	+	393	WP_004255705.1	chemotaxis response regulator CheY	-
H0904_RS08255	1827210..1827848	+	639	WP_094961165.1	protein phosphatase CheZ	-
H0904_RS08260	1828019..1828252	+	234	WP_080544466.1	helix-turn-helix domain-containing protein	-
H0904_RS08265	1828295..1828852	-	558	WP_144141262.1	hypothetical protein	-
H0904_RS08270	1828868..1829176	-	309	WP_144141264.1	CcdB family protein	Toxin
H0904_RS08275	1829176..1829403	-	228	WP_004255691.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
H0904_RS08280	1829667..1830818	+	1152	WP_140170721.1	flagellar type III secretion system protein FlhB	-
H0904_RS08285	1830811..1832910	+	2100	WP_004255687.1	flagellar biosynthesis protein FlhA	-
H0904_RS08290	1833680..1834120	-	441	WP_004255682.1	flagellar export chaperone FlgN	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-101)

Antitoxin

• Post-segregation antitoxin CcdA (5-75)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11757.87 Da
• Isoelectric Point: 8.0469

>T168580 WP_144141264.1 NZ_CP059298:c1829176-1828868 [Providencia rettgeri]
MQYRLYQNRDDAIKYPYLLDIQSNIIDLLNTRLVIPLFDSRLVKKPLPARLTPQLVINGQVFILMTHQMACVPHSLLGKE
IVDLSSQRDTIKHAIDLLIDGF

Nucleotide

• Length: 309 bp

>T168580 NZ_CP059298:c1829176-1828868 [Providencia rettgeri]
ATGCAATATCGCCTCTATCAAAACCGAGATGATGCTATCAAATACCCATATTTACTGGATATTCAAAGTAATATTATTGA
TTTATTGAATACTCGCTTAGTCATCCCGTTATTCGATAGCAGGCTAGTTAAAAAGCCATTACCCGCTCGCTTAACCCCCC
AATTAGTTATCAACGGGCAGGTTTTTATTTTAATGACTCACCAAATGGCTTGCGTCCCTCATTCATTATTAGGGAAAGAA
ATCGTTGACTTAAGTAGCCAACGAGACACCATTAAACACGCAATTGACTTACTGATTGATGGCTTTTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8688.92 Da
• Isoelectric Point: 8.9375

>AT168580 WP_004255691.1 NZ_CP059298:c1829403-1829176 [Providencia rettgeri]
MNRTKKTVSVTVAPELYEQARRAKLNLSAILACALQAELKRLEAQKWKNDNVEGFNELNRINEEYGLLSDKYKDF

Nucleotide

• Length: 228 bp

>AT168580 NZ_CP059298:c1829403-1829176 [Providencia rettgeri]
ATGAATAGAACAAAAAAAACCGTCAGTGTCACTGTCGCGCCTGAACTCTACGAACAAGCAAGGCGGGCTAAACTTAACTT
ATCAGCAATACTGGCTTGTGCCTTACAAGCTGAATTAAAACGCCTCGAAGCGCAAAAATGGAAAAATGACAATGTCGAAG
GCTTTAATGAGTTAAACAGGATAAATGAAGAATATGGATTACTCTCAGATAAATACAAGGATTTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A6G6Q922