Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2646492..2647077 Replicon chromosome
Accession NZ_CP059297
Organism Brevundimonas sp. AJA228-03

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HZ989_RS13295 Protein ID WP_209321277.1
Coordinates 2646492..2646680 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HZ989_RS13300 Protein ID WP_209321278.1
Coordinates 2646685..2647077 (+) Length 131 a.a.

Genomic Context


HZ989_RS13290HZ989_RS13295HZ989_RS13300HZ989_RS13305HZ989_RS13310HZ989_RS13315HZ989_RS13320HZ989_RS13325HZ989_RS13275HZ989_RS13280HZ989_RS13285
Location: 2643973..2645823 (1851 bp)
Type: Others
Protein ID: WP_209321276.1
Location: 2646492..2646680 (189 bp)
Type: Toxin
Protein ID: WP_209321277.1
Location: 2646685..2647077 (393 bp)
Type: Antitoxin
Protein ID: WP_209321278.1
Location: 2647134..2648168 (1035 bp)
Type: Others
Protein ID: WP_209321279.1
Location: 2648222..2648980 (759 bp)
Type: Others
Protein ID: WP_209321280.1
Location: 2648977..2649738 (762 bp)
Type: Others
Protein ID: WP_209321281.1
Location: 2649814..2650653 (840 bp)
Type: Others
Protein ID: WP_209321282.1
Location: 2650650..2651780 (1131 bp)
Type: Others
Protein ID: WP_209321283.1
Location: 2642726..2643202 (477 bp)
Type: Others
Protein ID: WP_256435891.1
Location: 2643199..2643555 (357 bp)
Type: Others
Protein ID: WP_209321274.1
Location: 2643552..2643806 (255 bp)
Type: Others
Protein ID: WP_209321275.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HZ989_RS13275 (HZ989_13260)2642726..2643202-477WP_256435891.1YcgN family cysteine cluster protein-
HZ989_RS13280 (HZ989_13265)2643199..2643555-357WP_209321274.1type II toxin-antitoxin system HicB family antitoxin-
HZ989_RS13285 (HZ989_13270)2643552..2643806-255WP_209321275.1type II toxin-antitoxin system HicA family toxin-
HZ989_RS13290 (HZ989_13275)2643973..2645823+1851WP_209321276.1ABC-F family ATP-binding cassette domain-containing protein-
HZ989_RS13295 (HZ989_13280)2646492..2646680+189WP_209321277.1type II toxin-antitoxin system HicA family toxinToxin
HZ989_RS13300 (HZ989_13285)2646685..2647077+393WP_209321278.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
HZ989_RS13305 (HZ989_13290)2647134..2648168+1035WP_209321279.1ABC transporter substrate-binding protein-
HZ989_RS13310 (HZ989_13295)2648222..2648980+759WP_209321280.1ABC transporter ATP-binding protein-
HZ989_RS13315 (HZ989_13300)2648977..2649738+762WP_209321281.1ABC transporter permease-
HZ989_RS13320 (HZ989_13305)2649814..2650653+840WP_209321282.1hypothetical protein-
HZ989_RS13325 (HZ989_13310)2650650..2651780+1131WP_209321283.1DUF2336 domain-containing protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--2620815..264707726262


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 63 a.a.        Molecular weight: 7141.33 Da        Isoelectric Point: 11.8888

>T168574 WP_209321277.1 NZ_CP059297:2646492-2646680 [Brevundimonas sp. AJA228-03]
MNSRDVIKALHADGWIEVAHKGSHKQFRHPIKPGRVTVPHPKRDFPIATLRSIERQAQIVLR

Download         Length: 189 bp

>T168574 NZ_CP076120:2158402-2159739 [Ralstonia solanacearum]
ATGGCGCATCCCGAACTGCATCTGTGGATGAACGGCGAGCATGTCGGCATCTGGACCGCCAGCCGCGCCGGCGTGCCGAT
CCTGCGCTATGACGACGCCTGGCTGCGCTCGCCCAACATGCGGCCGCTGTCGCTGTCGCTGCCGATCCCGGCCGGTGTGC
CCGAGCTGCGCGGCCAGGTGGTCGACGACTACTTCGACAACCTGCTGCCCGAGGCCCAGCCCATCCGCGAGCGCGTGCGG
CGCCGCTTCGGCCTCGCCTCCACAGATGCCGCCGAATTGCTGGCCGCCATCGGCCGCGACTGCGTGGGCGCCGTGCAACT
GCTGCCGCCCGGCATGGCCCCCACCGGCTACGACCGCATCGACAGCGAGCCGCTCACCGACAGCCAGGTCGACACGCTGC
TGCGCAACCTCACCGCCACGCCCGCGCTGGGCGAGGACGCCGGCGACCCCGACGCCTTCCGCATCTCCATTGCCGGCGCG
CAGGAGAAAACCGCCCTGCTGCGCATCGGCGATGCCTGGCACCGGCCGCTGGGCGCCACGCCCACCACGCACATCCTCAA
GCTGCCGCTGGGGCTGATCGGCAACATCCGCGCCGACATGCAGGACTCGGTCGACAACGAATGGCTGTGCGCGCAGCTGC
TGGCGGCCTGGGGGCTGGAGGTGGCGCGCACCGAGATCGCCCGCTTCGGCGCCAGCAAAGTGCTGGCGGTCGAGCGCTTC
GACCGCCGCTGGATGCCGGGCAACGCCTGGATCGCGCGCCTGCCGCAGGAAGACTTCTGCCAGGCCACCGGCACGCCCGC
GCACCGCAAATACGAAAACGACGGCGGCCCCGGCATGCGCGCCTGCCTCGACCTGCTGTCCGCGTCCGAACACGCCATCG
ACGACAAGCGCCGCTTCGTGCTGGCGCAACTTGCCTTCTGGCTGCTGGCCGCCACCGACGGGCACGCGAAGAACTTCTCG
CTGGCGATCGGGCGCGGCGGGCGCTTCCGCATGACGCCGCTGTATGACGTGCTCTCGGTCTGGCCGATCATGGGCGACGG
GCCGAACCAGCTGTCGCCCTATCGCGCGCGGCTGGCGATGGCCCTGCGCGGCAAGAACGCGCATGCGCGGCTGGCCGACA
TCCACGTGCGCCACTGGCAGGCGCTGGCGGCGCAATCCGGCGTGCCGGACGCGTTCGCCGGCATGCAGGCGCTGGTCGAG
CGCGTGCCGGCGGGTCTCGAGCGGGTCGAGGCGATCCTGCCGCCCGACTTCTCGGGCCGGGTCTGGAGCAGCGTGCGCAC
CGGCGTGCTCGCGCAGGCCGAGCGCTTTCTCAACGAACTGGCGTCCGTCACCCCATGA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 13988.65 Da        Isoelectric Point: 4.3465

>AT168574 WP_209321278.1 NZ_CP059297:2646685-2647077 [Brevundimonas sp. AJA228-03]
MAQFIALIHKDADSDYGVHFPDLPGLATAGTTLDEARAFAEEALVLHLEGLAEDGEPIPEASSLETIMNDPGNRDGVAIL
VRAETRSRAVRVNITLPEDALRDIDTYAEAHGFTRSGFLAQAARKLMQSA

Download         Length: 393 bp

>AT168574 NZ_CP076120:2158153-2158398 [Ralstonia solanacearum]
ATGGAGTCCCTGCTCTCCTCGGCGCCGCAGCTGTCGGCGCATCTGAAATCGTTGCGCAAGGCGCGCGGACTCACGCAGGC
CCAGTTGGGCGCACTGCTGGGCGTCAGCCAGAACCGCATCGCCGACATCGAAAAAGACCCGGGCGCGGTCGGCTTCGAGC
AGTTGCTGCGCATCCTGCACGCGCTCGGCGCGCAGCTGACGCTGCGCACGTCCGCGCCCGCCGCCGCCGCGCCCGCCGAC
TGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
No matching records found

References