Detailed information of TA system TA168574

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2646492..2647077
• Replicon: chromosome
• Accession: NZ_CP059297
• Organism: Brevundimonas sp. AJA228-03

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HZ989_RS13295
• Protein ID: WP_209321277.1
• Coordinates: 2646492..2646680 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HZ989_RS13300
• Protein ID: WP_209321278.1
• Coordinates: 2646685..2647077 (+)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZ989_RS13275 (HZ989_13260)	2642726..2643202	-	477	WP_256435891.1	YcgN family cysteine cluster protein	-
HZ989_RS13280 (HZ989_13265)	2643199..2643555	-	357	WP_209321274.1	type II toxin-antitoxin system HicB family antitoxin	-
HZ989_RS13285 (HZ989_13270)	2643552..2643806	-	255	WP_209321275.1	type II toxin-antitoxin system HicA family toxin	-
HZ989_RS13290 (HZ989_13275)	2643973..2645823	+	1851	WP_209321276.1	ABC-F family ATP-binding cassette domain-containing protein	-
HZ989_RS13295 (HZ989_13280)	2646492..2646680	+	189	WP_209321277.1	type II toxin-antitoxin system HicA family toxin	Toxin
HZ989_RS13300 (HZ989_13285)	2646685..2647077	+	393	WP_209321278.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HZ989_RS13305 (HZ989_13290)	2647134..2648168	+	1035	WP_209321279.1	ABC transporter substrate-binding protein	-
HZ989_RS13310 (HZ989_13295)	2648222..2648980	+	759	WP_209321280.1	ABC transporter ATP-binding protein	-
HZ989_RS13315 (HZ989_13300)	2648977..2649738	+	762	WP_209321281.1	ABC transporter permease	-
HZ989_RS13320 (HZ989_13305)	2649814..2650653	+	840	WP_209321282.1	hypothetical protein	-
HZ989_RS13325 (HZ989_13310)	2650650..2651780	+	1131	WP_209321283.1	DUF2336 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2620815..2647077	26262

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-123)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7141.33 Da
• Isoelectric Point: 11.8888

>T168574 WP_209321277.1 NZ_CP059297:2646492-2646680 [Brevundimonas sp. AJA228-03]
MNSRDVIKALHADGWIEVAHKGSHKQFRHPIKPGRVTVPHPKRDFPIATLRSIERQAQIVLR

Nucleotide

• Length: 189 bp

>T168574 NZ_CP076120:2158402-2159739 [Ralstonia solanacearum]
ATGGCGCATCCCGAACTGCATCTGTGGATGAACGGCGAGCATGTCGGCATCTGGACCGCCAGCCGCGCCGGCGTGCCGAT
CCTGCGCTATGACGACGCCTGGCTGCGCTCGCCCAACATGCGGCCGCTGTCGCTGTCGCTGCCGATCCCGGCCGGTGTGC
CCGAGCTGCGCGGCCAGGTGGTCGACGACTACTTCGACAACCTGCTGCCCGAGGCCCAGCCCATCCGCGAGCGCGTGCGG
CGCCGCTTCGGCCTCGCCTCCACAGATGCCGCCGAATTGCTGGCCGCCATCGGCCGCGACTGCGTGGGCGCCGTGCAACT
GCTGCCGCCCGGCATGGCCCCCACCGGCTACGACCGCATCGACAGCGAGCCGCTCACCGACAGCCAGGTCGACACGCTGC
TGCGCAACCTCACCGCCACGCCCGCGCTGGGCGAGGACGCCGGCGACCCCGACGCCTTCCGCATCTCCATTGCCGGCGCG
CAGGAGAAAACCGCCCTGCTGCGCATCGGCGATGCCTGGCACCGGCCGCTGGGCGCCACGCCCACCACGCACATCCTCAA
GCTGCCGCTGGGGCTGATCGGCAACATCCGCGCCGACATGCAGGACTCGGTCGACAACGAATGGCTGTGCGCGCAGCTGC
TGGCGGCCTGGGGGCTGGAGGTGGCGCGCACCGAGATCGCCCGCTTCGGCGCCAGCAAAGTGCTGGCGGTCGAGCGCTTC
GACCGCCGCTGGATGCCGGGCAACGCCTGGATCGCGCGCCTGCCGCAGGAAGACTTCTGCCAGGCCACCGGCACGCCCGC
GCACCGCAAATACGAAAACGACGGCGGCCCCGGCATGCGCGCCTGCCTCGACCTGCTGTCCGCGTCCGAACACGCCATCG
ACGACAAGCGCCGCTTCGTGCTGGCGCAACTTGCCTTCTGGCTGCTGGCCGCCACCGACGGGCACGCGAAGAACTTCTCG
CTGGCGATCGGGCGCGGCGGGCGCTTCCGCATGACGCCGCTGTATGACGTGCTCTCGGTCTGGCCGATCATGGGCGACGG
GCCGAACCAGCTGTCGCCCTATCGCGCGCGGCTGGCGATGGCCCTGCGCGGCAAGAACGCGCATGCGCGGCTGGCCGACA
TCCACGTGCGCCACTGGCAGGCGCTGGCGGCGCAATCCGGCGTGCCGGACGCGTTCGCCGGCATGCAGGCGCTGGTCGAG
CGCGTGCCGGCGGGTCTCGAGCGGGTCGAGGCGATCCTGCCGCCCGACTTCTCGGGCCGGGTCTGGAGCAGCGTGCGCAC
CGGCGTGCTCGCGCAGGCCGAGCGCTTTCTCAACGAACTGGCGTCCGTCACCCCATGA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 13988.65 Da
• Isoelectric Point: 4.3465

>AT168574 WP_209321278.1 NZ_CP059297:2646685-2647077 [Brevundimonas sp. AJA228-03]
MAQFIALIHKDADSDYGVHFPDLPGLATAGTTLDEARAFAEEALVLHLEGLAEDGEPIPEASSLETIMNDPGNRDGVAIL
VRAETRSRAVRVNITLPEDALRDIDTYAEAHGFTRSGFLAQAARKLMQSA

Nucleotide

• Length: 393 bp

>AT168574 NZ_CP076120:2158153-2158398 [Ralstonia solanacearum]
ATGGAGTCCCTGCTCTCCTCGGCGCCGCAGCTGTCGGCGCATCTGAAATCGTTGCGCAAGGCGCGCGGACTCACGCAGGC
CCAGTTGGGCGCACTGCTGGGCGTCAGCCAGAACCGCATCGCCGACATCGAAAAAGACCCGGGCGCGGTCGGCTTCGAGC
AGTTGCTGCGCATCCTGCACGCGCTCGGCGCGCAGCTGACGCTGCGCACGTCCGCGCCCGCCGCCGCCGCGCCCGCCGAC
TGGTAA