Detailed information of TA system TA168573

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 2643199..2643806
• Replicon: chromosome
• Accession: NZ_CP059297
• Organism: Brevundimonas sp. AJA228-03

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HZ989_RS13285
• Protein ID: WP_209321275.1
• Coordinates: 2643552..2643806 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HZ989_RS13280
• Protein ID: WP_209321274.1
• Coordinates: 2643199..2643555 (-)
• Length: 119 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZ989_RS13260 (HZ989_13245)	2639369..2639785	-	417	WP_209321270.1	hypothetical protein	-
HZ989_RS13265 (HZ989_13250)	2639910..2640293	-	384	WP_209321271.1	response regulator	-
HZ989_RS13270 (HZ989_13255)	2640290..2642656	-	2367	WP_209321272.1	PAS domain S-box protein	-
HZ989_RS13275 (HZ989_13260)	2642726..2643202	-	477	WP_256435891.1	YcgN family cysteine cluster protein	-
HZ989_RS13280 (HZ989_13265)	2643199..2643555	-	357	WP_209321274.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HZ989_RS13285 (HZ989_13270)	2643552..2643806	-	255	WP_209321275.1	type II toxin-antitoxin system HicA family toxin	Toxin
HZ989_RS13290 (HZ989_13275)	2643973..2645823	+	1851	WP_209321276.1	ABC-F family ATP-binding cassette domain-containing protein	-
HZ989_RS13295 (HZ989_13280)	2646492..2646680	+	189	WP_209321277.1	type II toxin-antitoxin system HicA family toxin	-
HZ989_RS13300 (HZ989_13285)	2646685..2647077	+	393	WP_209321278.1	type II toxin-antitoxin system HicB family antitoxin	-
HZ989_RS13305 (HZ989_13290)	2647134..2648168	+	1035	WP_209321279.1	ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2620815..2647077	26262

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-72)

Antitoxin

• Uncharacterised protein family HicB (54-104)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9296.74 Da
• Isoelectric Point: 10.5900

>T168573 WP_209321275.1 NZ_CP059297:c2643806-2643552 [Brevundimonas sp. AJA228-03]
MNSKHTKTLSAVFADPVSGTIEWAAIENLLVAVGCHIVEGAGSRVRFVRGVEAEFFHRPHPAREAKRYQVRAARAFLIRL
GVEP

Nucleotide

• Length: 255 bp

>T168573 NZ_CP076120:437429-437842 [Ralstonia solanacearum]
ATGCCCGCGACTGAGGCATTCTTCGACAGCAATGTCGTGCTGTACCTGCTGTCGGCCGACACCGCCAAGGCCGATGCGGC
GGAAACGCTGCTGATGACCGGCGGTGTCGTCAGCGTACAGGTACTGAACGAAACGACGCACGTGATGCGCCGCAAGCTGG
CCATGCCGTGGCACGCGATCGAAACGGTGCAGGAGGCCGTGCGTGCGCAATGCCGGGTCGAGCCGCTGACGCTCGAAACC
CATGATCTCGGACGGCGTATCGCAGAACGCTACGGATTGTCGGTCTATGACGCACTGATCGTCGCGGCGGCATTGCTTGC
CGGCTGCAACGTTCTGTATTCCGAGGATATGCAGCACGGCCTGGTGATCGAGCAGCATCTGCGCATCGTCAATCCTTTTC
CGGCACGGGCATGA

Antitoxin

Protein

• Length: 119 a.a.
• Molecular weight: 12863.53 Da
• Isoelectric Point: 5.2312

>AT168573 WP_209321274.1 NZ_CP059297:c2643555-2643199 [Brevundimonas sp. AJA228-03]
MSIMTYKGYSAAVEFDADDEIFFGKLAGIRDGVGFHADTARELKAAFREAVDDYIETCARIGKSPDKPYSGKVMFRVDPE
VHARVTKAAELSGRSLNAWAEDALRRAADADMAKAVAV

Nucleotide

• Length: 357 bp

>AT168573 NZ_CP076120:437209-437442 [Ralstonia solanacearum]
ATGCAAGTCTCGAAATGGGGCAACAGCCTCGCTATCCGGCTGCCGGCGGCCGTTGTGGAGGCGCTTCAGCTGCACGAAGG
CGACGACGTCGAGGTGGTGATCGCGGGCGAGCGCTCGTTTGGCGTCCGCCGCAAGCGCGCTGCGCGCGAGCTTTTCGACC
GGATCCACCAATATCGCGGCAAGCTGCCCGCCGATTTCATCTTCGAGCGCGACCAGGCCAATGCCCGCGACTGA