Detailed information of TA system TA168572

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2599415..2600058
• Replicon: chromosome
• Accession: NZ_CP059297
• Organism: Brevundimonas sp. AJA228-03

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HZ989_RS13045
• Protein ID: WP_209321232.1
• Coordinates: 2599415..2599825 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HZ989_RS13050
• Protein ID: WP_209321233.1
• Coordinates: 2599825..2600058 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZ989_RS13025 (HZ989_13015)	2595258..2596424	+	1167	WP_209321228.1	glycosyltransferase family 4 protein	-
HZ989_RS13030 (HZ989_13020)	2596472..2598037	+	1566	WP_209321229.1	alkaline phosphatase D family protein	-
HZ989_RS13035 (HZ989_13025)	2598141..2598590	+	450	WP_209321230.1	DUF305 domain-containing protein	-
HZ989_RS13040 (HZ989_13030)	2598594..2599418	-	825	WP_209321231.1	TIGR00282 family metallophosphoesterase	-
HZ989_RS13045 (HZ989_13035)	2599415..2599825	-	411	WP_209321232.1	PIN domain-containing protein	Toxin
HZ989_RS13050 (HZ989_13040)	2599825..2600058	-	234	WP_209321233.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
HZ989_RS13055 (HZ989_13045)	2600090..2600653	-	564	WP_245162371.1	5-formyltetrahydrofolate cyclo-ligase	-
HZ989_RS13060 (HZ989_13050)	2600644..2600865	-	222	WP_209321234.1	hypothetical protein	-
HZ989_RS13065 (HZ989_13055)	2601203..2601520	-	318	WP_209321235.1	cell division protein ZapA	-
HZ989_RS13070 (HZ989_13060)	2601520..2601774	-	255	WP_209321236.1	hypothetical protein	-
HZ989_RS13075 (HZ989_13065)	2601869..2603863	+	1995	WP_209321237.1	transketolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-125)

Antitoxin

• SpoVT-AbrB domain (9-56)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15146.29 Da
• Isoelectric Point: 6.3301

>T168572 WP_209321232.1 NZ_CP059297:c2599825-2599415 [Brevundimonas sp. AJA228-03]
MSLFMVDTSVCIRALRGRSRLLMDRFQEEADRIAISSVVLMELLYGAAVSARPRHHRSEVEDFVDRLMVLDLDSEAAAHA
ADIKADLRAKGTPIGVHDTLIAGHARSRSSILITGNLNEFKRVDGLRCDDWPDTQT

Nucleotide

• Length: 411 bp

>T168572 NZ_CP076119:c1319082-1318336 [Bacillus velezensis]
ATGCTTTTGTTTTTTCAGATTATGGTGTGGACGATGGCGGCCGCACTCATTTTATATGTGTACGCATCCTGGCGGTATGA
GGCAAAGGTAAAAGAAAAAATGTTTGCCATCCGTAAAACGTGGTATTTACTATTTGTACTGGGCTCCATGGTCTATTGGA
CATATGATCCCGAATCGCTCTTTGCCGCATGGAGACAATATTTGATTGTTGCCGTCTGCTTTGCCCTTATTGATGCGTTT
ATCTTTTTGAGCGCGTATATCAAAAAGCTCGCCGGCAATGAATTAGAGACGGATACGCGGGAAATTTTAGAAGAAAATAA
CGAAATGCTTCACTCCTATCTTGAAAAACTGAAAACCTATCAATATCTGTTGAAAAATGAACCGATCCATGTATATTATG
GAAGTACAGAAGCTTATGCGGAAGGCATCAGCAGACTGCTGGCCGCTTATGCCGAAAAAATGAATGTCACGGCTTCCTTG
TGCGACTATTCCGCACAATCGGATAAGGACCGCTTGACGGAGCATATGCCTGATGCGGCAGACGTTCAGTCCCGTCTTAA
CCGTAAAGACGTCTACTATGATCAAAAAGGCAGGCTTGTGCTTATTCCGTTTACAGTCCAAAACCGCCATTACGTGATCA
AACTCACGTCGGAAAACCTGTTGACGGAATTCGATTATTTGCTTTTCACATCGCTAACGAGCATTTATGATTTAATGCTG
CCAATAGAAGAGGAAGGTGACGGTTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8647.81 Da
• Isoelectric Point: 4.2545

>AT168572 WP_209321233.1 NZ_CP059297:c2600058-2599825 [Brevundimonas sp. AJA228-03]
MTLPRATVFRTNRSQAIRIPKAVAFPDDVKELVAIREGRGLLLVPPDDVWTSFFNRPGIDIEEPEDPIDDSPPVSFD

Nucleotide

• Length: 234 bp

>AT168572 NZ_CP076119:c1318335-1318165 [Bacillus velezensis]
ATGGAGCAGGCATTTCAAAACGGGCAGCCGGAACAAAGAGCGAAACCGTTCAAAATGTTTAAAAAACGTTCAATGACAAG
TATCGCAAGTTACCAGGTCAGCCCTCATACCGCCAGAATTTTCAAAGAAAACGAGCGGCTGATTGACAAGTATAAACAAA
AAAAAGCTTGA