Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-couple_hipB |
| Location | 1450917..1452562 | Replicon | chromosome |
| Accession | NZ_CP059297 | ||
| Organism | Brevundimonas sp. AJA228-03 | ||
Toxin (Protein)
| Gene name | HipA3 | Uniprot ID | - |
| Locus tag | HZ989_RS07205 | Protein ID | WP_209322919.1 |
| Coordinates | 1450917..1452218 (-) | Length | 434 a.a. |
Antitoxin (Protein)
| Gene name | HipB3 | Uniprot ID | - |
| Locus tag | HZ989_RS07210 | Protein ID | WP_209322920.1 |
| Coordinates | 1452215..1452562 (-) | Length | 116 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HZ989_RS07170 (HZ989_07180) | 1446665..1447918 | + | 1254 | WP_209322912.1 | tyrosine-type recombinase/integrase | - |
| HZ989_RS07175 (HZ989_07185) | 1447875..1448165 | - | 291 | WP_209322913.1 | AlpA family phage regulatory protein | - |
| HZ989_RS07180 (HZ989_07190) | 1448276..1448722 | - | 447 | WP_209322914.1 | helix-turn-helix domain-containing protein | - |
| HZ989_RS07185 (HZ989_07195) | 1448819..1449166 | + | 348 | WP_209322915.1 | hypothetical protein | - |
| HZ989_RS07190 (HZ989_07200) | 1449157..1449561 | + | 405 | WP_209322916.1 | hypothetical protein | - |
| HZ989_RS07195 (HZ989_07205) | 1449558..1449842 | + | 285 | WP_209322917.1 | hypothetical protein | - |
| HZ989_RS07200 (HZ989_07210) | 1449896..1450906 | + | 1011 | WP_209322918.1 | arsenic resistance protein | - |
| HZ989_RS07205 (HZ989_07215) | 1450917..1452218 | - | 1302 | WP_209322919.1 | HipA domain-containing protein | Toxin |
| HZ989_RS07210 (HZ989_07220) | 1452215..1452562 | - | 348 | WP_209322920.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| HZ989_RS07215 (HZ989_07225) | 1452747..1453217 | - | 471 | WP_209322921.1 | helix-turn-helix domain-containing protein | - |
| HZ989_RS07220 (HZ989_07230) | 1453293..1453958 | + | 666 | WP_209322922.1 | cation transporter | - |
| HZ989_RS07225 (HZ989_07235) | 1454057..1454377 | + | 321 | WP_209322923.1 | hypothetical protein | - |
| HZ989_RS07230 (HZ989_07240) | 1454432..1455691 | + | 1260 | WP_209322924.1 | TolC family protein | - |
| HZ989_RS07235 (HZ989_07245) | 1455688..1456848 | + | 1161 | WP_209322925.1 | efflux RND transporter periplasmic adaptor subunit | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 1407128..1489195 | 82067 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 434 a.a. Molecular weight: 47632.95 Da Isoelectric Point: 6.4012
>T168571 WP_209322919.1 NZ_CP059297:c1452218-1450917 [Brevundimonas sp. AJA228-03]
VTSVAEVRLWGRRIGAVSLEDGADVAAFAYDPAFITSGIQPAPLMMPLGPQVFTFPSLNRESFHGLPGLLADALPDRYGN
TLIDAWLATQGRTPESFNAVERLCYTGARGMGALEFTPALGPRPRKAARIQIDALVELASEVLSHRNDLQASFADARKAD
ALREILRVGTSAGGARAKAVIAWNAATNEVRSGQVEAGDGFDYWLLKFDGVKNNKDRELADPEGYGAVEYAYACMAAAAG
VQVAECRLLEEGGRRHFMTKRFDRLPGGGKLHMQSLAALAHYDFCDPNAYAYEQAFLVIRQLGLPMAAIEEQFRRMAFNI
IARNQDDHVKNIAFLMDRTGAWSLSPAYDITWSYNPTGLWTARHQMSMNGKRDGFTLDDFDASARVASINARRARAIVQE
VREAVARWPEFADAAQVGEDWRKSIDPSLRTVL
VTSVAEVRLWGRRIGAVSLEDGADVAAFAYDPAFITSGIQPAPLMMPLGPQVFTFPSLNRESFHGLPGLLADALPDRYGN
TLIDAWLATQGRTPESFNAVERLCYTGARGMGALEFTPALGPRPRKAARIQIDALVELASEVLSHRNDLQASFADARKAD
ALREILRVGTSAGGARAKAVIAWNAATNEVRSGQVEAGDGFDYWLLKFDGVKNNKDRELADPEGYGAVEYAYACMAAAAG
VQVAECRLLEEGGRRHFMTKRFDRLPGGGKLHMQSLAALAHYDFCDPNAYAYEQAFLVIRQLGLPMAAIEEQFRRMAFNI
IARNQDDHVKNIAFLMDRTGAWSLSPAYDITWSYNPTGLWTARHQMSMNGKRDGFTLDDFDASARVASINARRARAIVQE
VREAVARWPEFADAAQVGEDWRKSIDPSLRTVL
Download Length: 1302 bp
>T168571 NZ_CP076119:499238-499588 [Bacillus velezensis]
TTGATTGTAAAGCGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGCGTACGCCCGGT
TTTAGTGATCCAGAATGATATCGGAAATCGCTTTAGCCCGACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAAATAACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCCT
GCAAATCAGTTTGGCACTCATTGATTTTTAG
TTGATTGTAAAGCGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGCGTACGCCCGGT
TTTAGTGATCCAGAATGATATCGGAAATCGCTTTAGCCCGACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAAATAACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCCT
GCAAATCAGTTTGGCACTCATTGATTTTTAG
Antitoxin
Download Length: 116 a.a. Molecular weight: 12713.35 Da Isoelectric Point: 6.3484
>AT168571 WP_209322920.1 NZ_CP059297:c1452562-1452215 [Brevundimonas sp. AJA228-03]
MKITNLTTDDAALAEFGRRIADARLARQMTQAQFAQAAGVSKRTIERLEDGASTQSGNLVRCLRALDTLDGLDRLLPETP
PNPIALLERQGKMRQRARPTDAQEPAAPWTWGDEQ
MKITNLTTDDAALAEFGRRIADARLARQMTQAQFAQAAGVSKRTIERLEDGASTQSGNLVRCLRALDTLDGLDRLLPETP
PNPIALLERQGKMRQRARPTDAQEPAAPWTWGDEQ
Download Length: 348 bp
>AT168571 NZ_CP076119:498951-499232 [Bacillus velezensis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACTTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGGACAACTCGCCATAACC
GTGATTTGATGAGACGCGGGTATATGGAAATGGCGAAAATCAACTTGAATATCTCTTCTGAGGCTCACTATGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACTTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGGACAACTCGCCATAACC
GTGATTTGATGAGACGCGGGTATATGGAAATGGCGAAAATCAACTTGAATATCTCTTCTGAGGCTCACTATGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|