Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1450917..1452562 Replicon chromosome
Accession NZ_CP059297
Organism Brevundimonas sp. AJA228-03

Toxin (Protein)


Gene name HipA3 Uniprot ID -
Locus tag HZ989_RS07205 Protein ID WP_209322919.1
Coordinates 1450917..1452218 (-) Length 434 a.a.

Antitoxin (Protein)


Gene name HipB3 Uniprot ID -
Locus tag HZ989_RS07210 Protein ID WP_209322920.1
Coordinates 1452215..1452562 (-) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZ989_RS07170 (HZ989_07180) 1446665..1447918 + 1254 WP_209322912.1 tyrosine-type recombinase/integrase -
HZ989_RS07175 (HZ989_07185) 1447875..1448165 - 291 WP_209322913.1 AlpA family phage regulatory protein -
HZ989_RS07180 (HZ989_07190) 1448276..1448722 - 447 WP_209322914.1 helix-turn-helix domain-containing protein -
HZ989_RS07185 (HZ989_07195) 1448819..1449166 + 348 WP_209322915.1 hypothetical protein -
HZ989_RS07190 (HZ989_07200) 1449157..1449561 + 405 WP_209322916.1 hypothetical protein -
HZ989_RS07195 (HZ989_07205) 1449558..1449842 + 285 WP_209322917.1 hypothetical protein -
HZ989_RS07200 (HZ989_07210) 1449896..1450906 + 1011 WP_209322918.1 arsenic resistance protein -
HZ989_RS07205 (HZ989_07215) 1450917..1452218 - 1302 WP_209322919.1 HipA domain-containing protein Toxin
HZ989_RS07210 (HZ989_07220) 1452215..1452562 - 348 WP_209322920.1 helix-turn-helix transcriptional regulator Antitoxin
HZ989_RS07215 (HZ989_07225) 1452747..1453217 - 471 WP_209322921.1 helix-turn-helix domain-containing protein -
HZ989_RS07220 (HZ989_07230) 1453293..1453958 + 666 WP_209322922.1 cation transporter -
HZ989_RS07225 (HZ989_07235) 1454057..1454377 + 321 WP_209322923.1 hypothetical protein -
HZ989_RS07230 (HZ989_07240) 1454432..1455691 + 1260 WP_209322924.1 TolC family protein -
HZ989_RS07235 (HZ989_07245) 1455688..1456848 + 1161 WP_209322925.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1407128..1489195 82067


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-116)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-68)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 47632.95 Da        Isoelectric Point: 6.4012

>T168571 WP_209322919.1 NZ_CP059297:c1452218-1450917 [Brevundimonas sp. AJA228-03]
VTSVAEVRLWGRRIGAVSLEDGADVAAFAYDPAFITSGIQPAPLMMPLGPQVFTFPSLNRESFHGLPGLLADALPDRYGN
TLIDAWLATQGRTPESFNAVERLCYTGARGMGALEFTPALGPRPRKAARIQIDALVELASEVLSHRNDLQASFADARKAD
ALREILRVGTSAGGARAKAVIAWNAATNEVRSGQVEAGDGFDYWLLKFDGVKNNKDRELADPEGYGAVEYAYACMAAAAG
VQVAECRLLEEGGRRHFMTKRFDRLPGGGKLHMQSLAALAHYDFCDPNAYAYEQAFLVIRQLGLPMAAIEEQFRRMAFNI
IARNQDDHVKNIAFLMDRTGAWSLSPAYDITWSYNPTGLWTARHQMSMNGKRDGFTLDDFDASARVASINARRARAIVQE
VREAVARWPEFADAAQVGEDWRKSIDPSLRTVL

Download         Length: 1302 bp

>T168571 NZ_CP076119:499238-499588 [Bacillus velezensis]
TTGATTGTAAAGCGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGCGTACGCCCGGT
TTTAGTGATCCAGAATGATATCGGAAATCGCTTTAGCCCGACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAAATAACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCCT
GCAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 12713.35 Da        Isoelectric Point: 6.3484

>AT168571 WP_209322920.1 NZ_CP059297:c1452562-1452215 [Brevundimonas sp. AJA228-03]
MKITNLTTDDAALAEFGRRIADARLARQMTQAQFAQAAGVSKRTIERLEDGASTQSGNLVRCLRALDTLDGLDRLLPETP
PNPIALLERQGKMRQRARPTDAQEPAAPWTWGDEQ

Download         Length: 348 bp

>AT168571 NZ_CP076119:498951-499232 [Bacillus velezensis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACTTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGGACAACTCGCCATAACC
GTGATTTGATGAGACGCGGGTATATGGAAATGGCGAAAATCAACTTGAATATCTCTTCTGAGGCTCACTATGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References