Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-RHH
Location 309335..309909 Replicon chromosome
Accession NZ_CP059297
Organism Brevundimonas sp. AJA228-03

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HZ989_RS01645 Protein ID WP_209321916.1
Coordinates 309335..309700 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HZ989_RS01650 Protein ID WP_209321917.1
Coordinates 309694..309909 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZ989_RS01620 (HZ989_01620) 305005..306180 - 1176 WP_209323011.1 aspartate aminotransferase family protein -
HZ989_RS01625 (HZ989_01625) 306406..307227 - 822 WP_209321912.1 ABC transporter permease -
HZ989_RS01630 (HZ989_01630) 307372..308766 - 1395 WP_209321913.1 dihydrolipoyl dehydrogenase -
HZ989_RS01635 (HZ989_01635) 308770..308943 - 174 WP_209321914.1 hypothetical protein -
HZ989_RS01640 (HZ989_01640) 309201..309332 - 132 WP_209321915.1 2-oxo acid dehydrogenase subunit E2 -
HZ989_RS01645 (HZ989_01645) 309335..309700 - 366 WP_209321916.1 type II toxin-antitoxin system VapC family toxin Toxin
HZ989_RS01650 (HZ989_01650) 309694..309909 - 216 WP_209321917.1 ribbon-helix-helix protein, CopG family Antitoxin
HZ989_RS01655 (HZ989_01655) 309971..311713 - 1743 WP_209321918.1 2-oxo acid dehydrogenase subunit E2 -
HZ989_RS01660 (HZ989_01660) 311713..312840 - 1128 WP_209321919.1 alpha-ketoacid dehydrogenase subunit beta -
HZ989_RS01665 (HZ989_01665) 312988..314220 - 1233 WP_209321920.1 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) subunit alpha -
HZ989_RS01670 (HZ989_01670) 314365..314856 + 492 WP_209321921.1 Lrp/AsnC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 304049..305008 959


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-106)

Antitoxin

Ribbon-helix-helix protein, CopG

(7-40)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13437.21 Da        Isoelectric Point: 4.5551

>T168568 WP_209321916.1 NZ_CP059297:c309700-309335 [Brevundimonas sp. AJA228-03]
MVKALFDTNILIDHLNAAPEADAEIDRYDDRAISIISWIEVMAGAGPDLAEPTRTYLDGYQIVGLEDRIAEQAASLRQSR
RLKLPDAVIWATAQTTGRLLVTRNTKDFPADDPGVRAPYRI

Download         Length: 366 bp

>T168568 NZ_CP076116:1521232-1521576 [Ralstonia solanacearum]
ATGGATGCTACCTTTATCGAGTTGCCGCCTTTTCAGAGGCTGCGGGAGCACTATCTCTCGGACGACGAGTACCGAGCGCT
CCAGCAGGAACTGCTGGCCCGGCCGGACGCCGGCGACGTCATCAAGGGGACAGGTGGCCTACGCAAGCTGCGATTTTCGG
ACAAGCGGCGCGGCAAAGGTAAGCGCGGCGGTCTGCGCGTGATTTACTACCACTGGGATGGAGGCGGCCAATTCTGGATG
TTTGTCGTCTACGACAAGGGCGAGGCGGACGACCTTTCCAGCGACGAGCGCAAAGTGCTGGCACGGCTGCTGGAGCAGGA
AGTCAAGGCAAGGAGTGAGCGATGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7999.02 Da        Isoelectric Point: 8.5613

>AT168568 WP_209321917.1 NZ_CP059297:c309909-309694 [Brevundimonas sp. AJA228-03]
MRILVDANEDQVAALDALAKREKRPRAAVIRAAIDDYVARNKRQAVKDGFGLWGQGGEDGLAYQERLRSEW

Download         Length: 216 bp

>AT168568 NZ_CP076116:1521573-1521884 [Ralstonia solanacearum]
ATGAAACGGAACCTGTTTGCTGAGTTGAAGGAGGGGATGGATGCGCTTGCCGCAGAGCGCGAAGGAAAGATGACCCTTCG
CAAGGTGAAGGTCCGCGTGCTCCAGCCGCTTGACGTGACAGCCGAAGAAATCAAGGCCGTTCGCGCAGCGGCACATGCTT
CACAGGCTGTCATGGCACGTCGACTGCGCGTCAATGTGCGCACCTACCAGAACTGGGAACAAGGAACCGCCAAACCGAAC
ACCCAGGCGGCTGTGTTGATCAAGCTCGTCGAGAAGCATCCGGAAACGTTGCAGATGCTGGAAGCGCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References