Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 8560..9470 | Replicon | plasmid pER17974.3 |
| Accession | NZ_CP059296 | ||
| Organism | Klebsiella pneumoniae strain ER17974.3 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A663AYG0 |
| Locus tag | H0490_RS25945 | Protein ID | WP_004026354.1 |
| Coordinates | 8560..9030 (-) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A6P1V3Q9 |
| Locus tag | H0490_RS25950 | Protein ID | WP_004026357.1 |
| Coordinates | 9027..9470 (-) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H0490_RS25910 (H0490_25865) | 3922..4083 | + | 162 | WP_164507110.1 | hypothetical protein | - |
| H0490_RS25915 (H0490_25870) | 4200..4364 | + | 165 | WP_011154586.1 | hypothetical protein | - |
| H0490_RS25920 (H0490_25875) | 4440..4682 | + | 243 | WP_071826037.1 | hypothetical protein | - |
| H0490_RS25925 (H0490_25880) | 5061..5219 | - | 159 | WP_004181898.1 | type I toxin-antitoxin system Hok family toxin | - |
| H0490_RS25930 (H0490_25885) | 5291..6472 | + | 1182 | WP_004883380.1 | IS481 family transposase | - |
| H0490_RS25935 (H0490_25890) | 7043..7303 | + | 261 | WP_004026352.1 | hypothetical protein | - |
| H0490_RS25940 (H0490_25895) | 7899..8105 | + | 207 | WP_004902422.1 | hypothetical protein | - |
| H0490_RS25945 (H0490_25900) | 8560..9030 | - | 471 | WP_004026354.1 | RES family NAD+ phosphorylase | Toxin |
| H0490_RS25950 (H0490_25905) | 9027..9470 | - | 444 | WP_004026357.1 | DUF2384 domain-containing protein | Antitoxin |
| H0490_RS25955 (H0490_25910) | 9571..10074 | - | 504 | Protein_15 | DUF4113 domain-containing protein | - |
| H0490_RS25960 (H0490_25915) | 10172..10393 | - | 222 | WP_004213643.1 | DUF2188 domain-containing protein | - |
| H0490_RS25965 (H0490_25920) | 10568..10693 | - | 126 | Protein_17 | Fe3+-citrate ABC transporter substrate-binding protein | - |
| H0490_RS25970 (H0490_25925) | 10768..12894 | - | 2127 | WP_029884227.1 | TonB-dependent Fe(3+) dicitrate receptor FecA | - |
| H0490_RS25975 (H0490_25930) | 12981..13934 | - | 954 | Protein_19 | fec operon regulator FecR | - |
| H0490_RS25980 (H0490_25935) | 13931..14452 | - | 522 | WP_004213635.1 | ferric citrate uptake sigma factor FecI | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | iroB / iroC / iroD / iroN / rmpA / rmpA / rmpA2 / iutA / iucD / iucC / iucB / iucA | 1..234967 | 234967 | |
| - | flank | IS/Tn | - | - | 5291..6472 | 1181 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17515.79 Da Isoelectric Point: 4.6155
>T168563 WP_004026354.1 NZ_CP059296:c9030-8560 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
>T168563 NZ_CP076113:2229645-2229935 [Pasteurella multocida]
ATGAGTAAAAAAGTAGAATTAAAACCATTTGATATTGCTGAATACCTAGATAGTGAAGAAATGATTGCAGCATATTTAAG
TGAAGTTTTAGAAACAGGTGGCACTAATGAATTTATTTCTGCGCTAGGTGATGTCGCAAGAGCGAGAGGAATGACGGAGT
TAGCAGAAAAAACGGGGTTGGGAAGAGAAAGCCTCTATAAAACATTATCATACGGTAGTAAGCCACGTTTTGATACTATA
ATGAAAATTACGCAAGCACTAGGTATTAAACTTGTCCCAACGCATATCTAA
ATGAGTAAAAAAGTAGAATTAAAACCATTTGATATTGCTGAATACCTAGATAGTGAAGAAATGATTGCAGCATATTTAAG
TGAAGTTTTAGAAACAGGTGGCACTAATGAATTTATTTCTGCGCTAGGTGATGTCGCAAGAGCGAGAGGAATGACGGAGT
TAGCAGAAAAAACGGGGTTGGGAAGAGAAAGCCTCTATAAAACATTATCATACGGTAGTAAGCCACGTTTTGATACTATA
ATGAAAATTACGCAAGCACTAGGTATTAAACTTGTCCCAACGCATATCTAA
Antitoxin
Download Length: 148 a.a. Molecular weight: 16480.80 Da Isoelectric Point: 10.2498
>AT168563 WP_004026357.1 NZ_CP059296:c9470-9027 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
>AT168563 NZ_CP076113:2229334-2229648 [Pasteurella multocida]
ATGCTCGATATAATTGAAACAACAGTATTTAATAAATGGCTTAAAGAGCTAGAAGATTTGTCGGCTAAGGCAGCTATTCT
TGCTCGTATTAGTCGCGCTAAAAGTGGTAATTTTGGCGATCACAAATCAGTTGGTGATGGTTTATATGAAATGCGAATAA
TGAAAGGAGCTGGTTATAGGGTTTATTATGCACAATACAAAGATGTAACCTATTTGCTAATTTGTGGCGGTGATAAATCT
ACTCAGAAAGCAGATATTGCTAAAGCAAAAGTGTTATGGGAAGAAATTAAGCAGAAAGAGGGGGTAAATGTATGA
ATGCTCGATATAATTGAAACAACAGTATTTAATAAATGGCTTAAAGAGCTAGAAGATTTGTCGGCTAAGGCAGCTATTCT
TGCTCGTATTAGTCGCGCTAAAAGTGGTAATTTTGGCGATCACAAATCAGTTGGTGATGGTTTATATGAAATGCGAATAA
TGAAAGGAGCTGGTTATAGGGTTTATTATGCACAATACAAAGATGTAACCTATTTGCTAATTTGTGGCGGTGATAAATCT
ACTCAGAAAGCAGATATTGCTAAAGCAAAAGTGTTATGGGAAGAAATTAAGCAGAAAGAGGGGGTAAATGTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A663AYG0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6P1V3Q9 |