Detailed information of TA system TA168562

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4058130..4059718
• Replicon: chromosome
• Accession: NZ_CP059295
• Organism: Klebsiella pneumoniae strain ER17974.3

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: W8UI36
• Locus tag: H0490_RS19390
• Protein ID: WP_002904792.1
• Coordinates: 4058130..4059452 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: H0490_RS19395
• Protein ID: WP_004176198.1
• Coordinates: 4059452..4059718 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0490_RS19375 (4053186)	4053186..4055687	+	2502	WP_029884184.1	fimbria/pilus outer membrane usher protein	-
H0490_RS19380 (4055675)	4055675..4056679	+	1005	WP_029884185.1	fimbrial protein	-
H0490_RS19385 (4056821)	4056821..4058113	+	1293	WP_016946381.1	glycoside hydrolase family 10 protein	-
H0490_RS19390 (4058130)	4058130..4059452	-	1323	WP_002904792.1	type II toxin-antitoxin system HipA family toxin	Toxin
H0490_RS19395 (4059452)	4059452..4059718	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
H0490_RS19400 (4060105)	4060105..4060431	-	327	WP_004224757.1	hydroxyisourate hydrolase	-
H0490_RS19405 (4060428)	4060428..4060928	-	501	WP_004224756.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
H0490_RS19410 (4060906)	4060906..4062285	-	1380	WP_014599164.1	nucleobase:cation symporter-2 family protein	-
H0490_RS19415 (4062631)	4062631..4063785	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
H0490_RS19420 (4063766)	4063766..4064689	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	mgtC / iroE	3884217..4102203	217986

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49171.46 Da
• Isoelectric Point: 7.5357

>T168562 WP_002904792.1 NZ_CP059295:c4059452-4058130 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T168562 NZ_CP076113:2229334-2229648 [Pasteurella multocida]
ATGCTCGATATAATTGAAACAACAGTATTTAATAAATGGCTTAAAGAGCTAGAAGATTTGTCGGCTAAGGCAGCTATTCT
TGCTCGTATTAGTCGCGCTAAAAGTGGTAATTTTGGCGATCACAAATCAGTTGGTGATGGTTTATATGAAATGCGAATAA
TGAAAGGAGCTGGTTATAGGGTTTATTATGCACAATACAAAGATGTAACCTATTTGCTAATTTGTGGCGGTGATAAATCT
ACTCAGAAAGCAGATATTGCTAAAGCAAAAGTGTTATGGGAAGAAATTAAGCAGAAAGAGGGGGTAAATGTATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT168562 WP_004176198.1 NZ_CP059295:c4059718-4059452 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT168562 NZ_CP076113:2229645-2229935 [Pasteurella multocida]
ATGAGTAAAAAAGTAGAATTAAAACCATTTGATATTGCTGAATACCTAGATAGTGAAGAAATGATTGCAGCATATTTAAG
TGAAGTTTTAGAAACAGGTGGCACTAATGAATTTATTTCTGCGCTAGGTGATGTCGCAAGAGCGAGAGGAATGACGGAGT
TAGCAGAAAAAACGGGGTTGGGAAGAGAAAGCCTCTATAAAACATTATCATACGGTAGTAAGCCACGTTTTGATACTATA
ATGAAAATTACGCAAGCACTAGGTATTAAACTTGTCCCAACGCATATCTAA

Structures

Toxin

• AlphaFold DB: A0A0E1CEC8