Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2145889..2146546 Replicon chromosome
Accession NZ_CP059295
Organism Klebsiella pneumoniae strain ER17974.3

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag H0490_RS10310 Protein ID WP_002916310.1
Coordinates 2146136..2146546 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag H0490_RS10305 Protein ID WP_002916312.1
Coordinates 2145889..2146155 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0490_RS10280 (2141097) 2141097..2142530 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
H0490_RS10285 (2142649) 2142649..2143377 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
H0490_RS10290 (2143427) 2143427..2143738 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
H0490_RS10295 (2143902) 2143902..2144561 + 660 WP_002916317.1 hemolysin III family protein -
H0490_RS10300 (2144660) 2144660..2145643 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
H0490_RS10305 (2145889) 2145889..2146155 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
H0490_RS10310 (2146136) 2146136..2146546 + 411 WP_002916310.1 protein YgfX Toxin
H0490_RS10315 (2146553) 2146553..2147074 - 522 WP_002916308.1 flavodoxin FldB -
H0490_RS10320 (2147175) 2147175..2148071 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
H0490_RS10325 (2148094) 2148094..2148807 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
H0490_RS10330 (2148813) 2148813..2150546 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T168553 WP_002916310.1 NZ_CP059295:2146136-2146546 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T168553 NZ_CP076105:c812262-812074 [Staphylococcus aureus subsp. aureus RN4220]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT168553 WP_002916312.1 NZ_CP059295:2145889-2146155 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT168553 NZ_CP076105:c812551-812291 [Staphylococcus aureus subsp. aureus RN4220]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References