Detailed information of TA system TA168548

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 943604..945285
• Replicon: chromosome
• Accession: NZ_CP059295
• Organism: Klebsiella pneumoniae strain ER17974.3

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: J2XCI1
• Locus tag: H0490_RS04500
• Protein ID: WP_004146663.1
• Coordinates: 943604..944521 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: H0490_RS04505
• Protein ID: WP_004177809.1
• Coordinates: 944527..945285 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0490_RS04480 (938910)	938910..940430	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
H0490_RS04485 (940427)	940427..941425	+	999	WP_004872882.1	ribose ABC transporter permease	-
H0490_RS04490 (941456)	941456..942397	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
H0490_RS04495 (942472)	942472..943479	+	1008	WP_004221949.1	carbohydrate kinase family protein	-
H0490_RS04500 (943604)	943604..944521	-	918	WP_004146663.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
H0490_RS04505 (944527)	944527..945285	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
H0490_RS04510 (945371)	945371..946099	-	729	WP_004177810.1	response regulator transcription factor	-
H0490_RS04515 (946372)	946372..948519	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
H0490_RS04520 (948981)	948981..949667	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34659.10 Da
• Isoelectric Point: 5.4707

>T168548 WP_004146663.1 NZ_CP059295:c944521-943604 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T168548 NZ_CP076104:2209698-2209979 [Nocardioides sp. LMS-CY]
GTGAGCACGAGCCCGCCGTACGAACTGGTCCTGGCCCCTCCGGCCGTCCGGGCCCTGCAGTCGGGGCTGCCGGAGCCGGT
GGCGACCGCGGTCATCGAGTTCCTCACCGGGCCGCTGCTCGAGAACCCGCAGCGGGTCGGGAAGGCGCTGCGTGGCGAGC
TGGCCGGTATCCGCGCGGCTCGGCGCGGCACCTACCGCGTGCTCTATCGCATCGACGACGAGGCCGATGAGATCCTCGTG
ATGCGCATCGAACACCGGGCGGAGGTGTATCGGCCGAGGTAG

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT168548 WP_004177809.1 NZ_CP059295:c945285-944527 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT168548 NZ_CP076104:2209435-2209701 [Nocardioides sp. LMS-CY]
ATGTCTGTCGAGCCGCTGCGCGAAGTTCGCAACCACTTCAGCGACGTCATTGATCGCGTCGAACGCGAGCACGAGCGGGT
TACGGTCACGCGCAACGGCCGGGCCGCGGCCGTCATCATCAGTCCCGACGACCTTGCCGAGCTGGAGGAGACCCTCGCCG
TGCTCAGCGATCCGCAGGCCATGGCCGACATCCGGGAGGCCGATGCCGCCTACCGCACCGGAGATGTCGTTCGCGGCGCG
GACGCGGTGCGGGCCCTTCGTCGGTGA

Structures

Toxin

• AlphaFold DB: J2XCI1

Antitoxin

• AlphaFold DB: A6TH05