Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 651806..652616 Replicon chromosome
Accession NZ_CP059295
Organism Klebsiella pneumoniae strain ER17974.3

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag H0490_RS03130 Protein ID WP_004178461.1
Coordinates 651806..652339 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID A0A483I2M4
Locus tag H0490_RS03135 Protein ID WP_004222378.1
Coordinates 652350..652616 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0490_RS03125 (650637) 650637..651758 + 1122 WP_002887282.1 cupin domain-containing protein -
H0490_RS03130 (651806) 651806..652339 - 534 WP_004178461.1 type II toxin-antitoxin system toxin KacT Toxin
H0490_RS03135 (652350) 652350..652616 - 267 WP_004222378.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
H0490_RS03140 (652719) 652719..654152 - 1434 WP_004222374.1 Cu(+)/Ag(+) sensor histidine kinase -
H0490_RS03145 (654142) 654142..654825 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
H0490_RS03150 (654997) 654997..656382 + 1386 WP_004222371.1 efflux transporter outer membrane subunit -
H0490_RS03155 (656400) 656400..656744 + 345 WP_004222368.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T168547 WP_004178461.1 NZ_CP059295:c652339-651806 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

>T168547 NZ_CP076104:2163307-2163735 [Nocardioides sp. LMS-CY]
GTGAGGGCACTCCTCGACGTCAACGTGCTCCTGGCGCTGCTCGACTCCGACCACGTGAGTCATCGGCGGGCCTGGGACTG
GCTGGACGCCGAGATCGACCAGGGATGGGCCTCGTGCCCGCTCACCCAGAACGGCTTCGTGCGGATCATCAGTCAGCCGC
GCTACCCGAACCCGATCCGTTCCGGCCAGGCGATCGAGCTGCTGCGGCAGGCGACCGCGACCGCTCACCACGAGTTCTGG
CCGGCGGAGGTCTCCGTGCTCGACGCCGAGCGGGTCCGCGCCGATCGCGTGCATGGACCGAAGCAGGTCACCGCCCTCTA
CCTGCTGGCACTCGCCGTGGCCCGCGGCGGCCGGCTCGTGACCTTCGACGAGTCGGTGCCGGTCTCGGCCGTGCCCGGCG
CAGGCCGTGATCACCTGACGCTGTTGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9969.44 Da        Isoelectric Point: 10.1757

>AT168547 WP_004222378.1 NZ_CP059295:c652616-652350 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLSEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp

>AT168547 NZ_CP076104:2163080-2163310 [Nocardioides sp. LMS-CY]
ATGCGCACCACTCTCGACATCGACGACGACGTGCTCATGGTCGCCAAGGAGCGCGCCCGACGCGAGCGTCGGTCGGCGGG
CGCGATCCTGTCGGAGCTCGCCCGGCAGGCGCTGAACGATGCATCGGACCAGGCCGCCCGCGCCGACTACGGATTCCGGC
CCCTGCCGTCCCGCGGCGGGCTGGTCACCAACACCCTGATCGACGAGATCGCCGCGGAACTCGAATCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
AlphaFold DB A0A483I2M4

References