Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 47584..48203 Replicon chromosome
Accession NZ_CP059295
Organism Klebsiella pneumoniae strain ER17974.3

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag H0490_RS00230 Protein ID WP_002892050.1
Coordinates 47985..48203 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag H0490_RS00225 Protein ID WP_002892066.1
Coordinates 47584..47958 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0490_RS00215 (42736) 42736..43929 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
H0490_RS00220 (43952) 43952..47098 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
H0490_RS00225 (47584) 47584..47958 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
H0490_RS00230 (47985) 47985..48203 + 219 WP_002892050.1 HHA domain-containing protein Toxin
H0490_RS00235 (48362) 48362..48928 + 567 WP_002892030.1 maltose O-acetyltransferase -
H0490_RS00240 (48900) 48900..49040 - 141 WP_004147370.1 hypothetical protein -
H0490_RS00245 (49061) 49061..49531 + 471 WP_002892026.1 YlaC family protein -
H0490_RS00250 (49538) 49538..50995 - 1458 WP_029883993.1 PLP-dependent aminotransferase family protein -
H0490_RS00255 (51096) 51096..51794 + 699 WP_002892021.1 GNAT family protein -
H0490_RS00260 (51791) 51791..51931 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
H0490_RS00265 (51931) 51931..52194 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T168546 WP_002892050.1 NZ_CP059295:47985-48203 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T168546 NZ_CP076104:c2081174-2080785 [Nocardioides sp. LMS-CY]
GTGAAGATCTACCTGGACTCGTCGGCAGCGACGAAGCTCGTCGTCGAGGAACCCGAGAGCGCTGCGCTCCTCGCGTACCT
GGAGGAGCGGGCGGCGTCGGCCGAGTTCGTGTCATCGATCCTGTTCGAGACCGAGCTCAGGCGCGCCGCGCGACGGCGCG
GCATCGATGAGGAGAACGTCACGGCGGCCGTCGACCTGGTCAACCTCGCCGAGGCGCCCCGTGCGGTGTTCAAGGTCGCC
GCGGCCATCGGACCGATGGCGCTCCGCAGCCTCGACGCCATCCACCTGGCCACCGCTCTGCGCGAGGACGTCGACGTCCT
CGTCACGTTCGACCGCCGCCTGCAGGACGCGGGCCGGGAGGCCGGGTTGGTGGTCGAGGCGCCGGCCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT168546 WP_002892066.1 NZ_CP059295:47584-47958 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT168546 NZ_CP076104:c2081461-2081171 [Nocardioides sp. LMS-CY]
ATGAGAGGCACGGTGAGTCGGCTGATGGAGCGCATTCCCCACCGTCGGCTCCGCAATGACAGTTCGGAGATCCTGCGCCG
GGTGGCCGACGGGGAGTCGTTCGAGATCACGAACAACGGCGAGGTCGTGGCCATCCTCGCTCCACCGACCGCGGCTGTGA
GCTGGAACCTCCGCATCGTGAAGCCCGCCGTCCGCAAGGGTGGCTGGTCGAGGTTGAAGCCAGTGCGGCTGCCGCCCGGA
TCGCCGGCGCTGAGCGAGACCCTCGACGAGTTGCGCGAGGAGCGGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References