Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 11079..11671 Replicon plasmid p1506-3-mcr
Accession NZ_CP059291
Organism Escherichia coli strain 1506

Toxin (Protein)


Gene name hicA Uniprot ID V0AGQ2
Locus tag H0481_RS23330 Protein ID WP_000520549.1
Coordinates 11423..11671 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID V0AWG0
Locus tag H0481_RS23325 Protein ID WP_000681613.1
Coordinates 11079..11426 (-) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0481_RS23295 7084..7356 - 273 WP_001328551.1 TrbC/VirB2 family protein -
H0481_RS23300 7424..8044 - 621 WP_000157549.1 lytic transglycosylase domain-containing protein -
H0481_RS23305 8400..8615 - 216 WP_000760375.1 EexN family lipoprotein -
H0481_RS23310 8612..8905 - 294 WP_060598542.1 LuxR family transcriptional regulator -
H0481_RS23315 8982..10211 - 1230 WP_001329504.1 relaxase/mobilization nuclease domain-containing protein -
H0481_RS23320 10215..10718 - 504 WP_000781813.1 hypothetical protein -
H0481_RS23325 11079..11426 - 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H0481_RS23330 11423..11671 - 249 WP_000520549.1 type II toxin-antitoxin system HicA family toxin Toxin
H0481_RS23335 11976..12326 - 351 WP_000854259.1 hypothetical protein -
H0481_RS23340 12417..12716 - 300 WP_000650309.1 hypothetical protein -
H0481_RS23345 13170..13397 - 228 WP_000801440.1 hypothetical protein -
H0481_RS23350 13384..13635 - 252 WP_001230707.1 hypothetical protein -
H0481_RS23355 13632..14174 - 543 WP_001083906.1 hypothetical protein -
H0481_RS23360 14279..14794 - 516 WP_001025395.1 J domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mcr-1.1 - 1..33309 33309


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9422.08 Da        Isoelectric Point: 10.4800

>T168544 WP_000520549.1 NZ_CP059291:c11671-11423 [Escherichia coli]
MGKTDKLLAKFLNSKKTFEWDELVVLFSSLGYVKKEMQGSRVRFFNAEINHTILMHRPHPESYIKGGTLKAIKQNLKEAG
LL

Download         Length: 249 bp

>T168544 NZ_CP076061:2475653-2475922 [Cupriavidus sp. EM10]
ATGACGCGCAACATCTTGTTCACCGCTGATGCGTGGGAGCAGTACCTCTTCTGGCAAGGGCAAGATCGGAAGACGCTAAG
GCGCATCAATCAGCTGGTCGATGATGCACGGCGGTCTCCCTTTGAGGGCATCGGAAAGCCCGAGCCCTTGAAAGGAAACC
TCGCAGGGTTCTGGTCGCGCCGCATCGATGACACCAATCGACTTGTCTATAAAGCCGACGACACTGCCGTCTCTATCGTC
AGCTGTCGCTATCACTATGGCGACAGGTAG

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13113.84 Da        Isoelectric Point: 4.6723

>AT168544 WP_000681613.1 NZ_CP059291:c11426-11079 [Escherichia coli]
MKHLKYKGYLGTVEPDFENNVLYGKLAFIRDLVTYEASTLAELEQEFKTSVDLYLQSCVEDGKEPDTPFKGVFNVRLDPE
LHRRVAEMAMEEDLSLNAFVNKALEKEVSNHRAGA

Download         Length: 348 bp

>AT168544 NZ_CP076061:2475387-2475656 [Cupriavidus sp. EM10]
ATGCGCACAGTTCATTTCTCGGATGCACGGAATAACCTCAAGGCCGTCATCGATCAGGCTATTGAGGATCACGACGCCGT
GCTGATCACTCGCCGGGATGCCCCCAACGCGGTCATCATGTCGCAGGAGCAATACGATAGCTGGGCGGAAACCATCTATC
TGCTCAACTCGCCGGCAAATGCCGCGCACCTCGCCCGCTCGCTGGAACAGTTGCGAGCCGGGGAAACGCAATCGCGAAAG
CTCATTGATCCGGACGATGCAGCGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CIX3

Antitoxin

Source ID Structure
AlphaFold DB A0A829CLC1

References