Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 70650..71251 Replicon plasmid p1506-2
Accession NZ_CP059290
Organism Escherichia coli strain 1506

Toxin (Protein)


Gene name doc Uniprot ID F4TND7
Locus tag H0481_RS23165 Protein ID WP_001216030.1
Coordinates 70871..71251 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag H0481_RS23160 Protein ID WP_001190712.1
Coordinates 70650..70871 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0481_RS23150 67766..68914 - 1149 WP_096165363.1 restriction endonuclease subunit S -
H0481_RS23155 68911..70467 - 1557 WP_061327181.1 type I restriction-modification system subunit M -
H0481_RS23160 70650..70871 + 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
H0481_RS23165 70871..71251 + 381 WP_001216030.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
H0481_RS23170 71256..71435 + 180 WP_112026184.1 PdcA protein -
H0481_RS23175 71463..72506 + 1044 WP_112026185.1 DUF968 domain-containing protein -
H0481_RS23180 72595..73047 + 453 WP_001312282.1 late promoter-activating protein (Gp10) -
H0481_RS23185 73134..74327 + 1194 WP_137441569.1 terminase -
H0481_RS23190 74327..75811 + 1485 WP_000124159.1 hypothetical protein -
H0481_RS23195 76033..76152 + 120 WP_001376634.1 ash family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..92457 92457


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13601.29 Da        Isoelectric Point: 5.1408

>T168543 WP_001216030.1 NZ_CP059290:70871-71251 [Escherichia coli]
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVAYEDITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

>T168543 NZ_CP076061:118159-118437 [Cupriavidus sp. EM10]
ATGATCGTGTCATCCAGTTGCCGCCTGACCCCGGCGTTGTTTGCGGGCCAGCGAGTTCCACGTTTTGTCAACTTCGGTAC
CACCGCCGAGCGGAAGTTGGCCATGCTGGAAGCCGCCGTCATCCTAGAAGACCTCGCGACGCCACCGGGAAATCGGCTCG
AGCGCCTGTACAGCGATCGTCCGGACCAGTACAGCATCCGGATCAACGATCAGTGGCGGATCTGTTTCACATGGACGTCT
GACGGCCCCGCCAATGTCGCCATCATCGATTACCACTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT168543 WP_001190712.1 NZ_CP059290:70650-70871 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp

>AT168543 NZ_CP076061:118476-118790 [Cupriavidus sp. EM10]
ATGCAGAAAATTGAAAACGGCCTGCGCCCGGTTCATCCGGGCGAAGTCCTTCGCGAGGAATTCCTTGTCCCCCTCGACAT
GACCGCCAACGCGCTGGCGGGAATGCTGCATGTCACGCCCGCGCGCATCAATGAGATCGTGCGCGGCGAACGGGGCGTCA
CTCCGGTCACGGCATTGCGGCTGGCCCGATACTTTGGAGGCACTGCGGAATTCTGGATGAACCTGCAGCAAACCTATGAC
CTGAAGATCGCCAGGCTGGAGCATGAGGCCGAGATATTTGCCGAGATCCAGCCGCGGCAGGTAAACCCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M1W8Q3

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References