Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3931622..3932198 Replicon chromosome
Accession NZ_CP059288
Organism Escherichia coli strain 1506

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag H0481_RS19185 Protein ID WP_001297643.1
Coordinates 3931911..3932198 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag H0481_RS19180 Protein ID WP_000063156.1
Coordinates 3931622..3931924 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0481_RS19165 3928218..3930368 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
H0481_RS19170 3930418..3930621 + 204 WP_000467859.1 YbdD/YjiX family protein -
H0481_RS19175 3930632..3931588 + 957 WP_181463919.1 GTPase -
H0481_RS19180 3931622..3931924 - 303 WP_000063156.1 BrnA antitoxin family protein Antitoxin
H0481_RS19185 3931911..3932198 - 288 WP_001297643.1 BrnT family toxin Toxin
H0481_RS19190 3932397..3933094 - 698 Protein_3751 IS1 family transposase -
H0481_RS19195 3933151..3933246 + 96 Protein_3752 dienelactone hydrolase family protein -
H0481_RS19200 3933392..3934624 + 1233 WP_063117540.1 multidrug efflux MFS transporter MdtM -
H0481_RS19205 3934665..3935945 + 1281 WP_181463920.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T168541 WP_001297643.1 NZ_CP059288:c3932198-3931911 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T168541 NZ_CP076060:185970-186266 [Cupriavidus sp. EM10]
ATGGAGAAATCGACAGCGCATTACAGGCTTGCCCAGGTGAGGGCATTGATTGCGGAAAGGCGGGTCGTGTTTACCGCATC
GGCTGCGCAGGGTCACCAGGCCATGTCGATGTCGCGCGCAGAGGCTTTGGCGGTGGTGGAAAAGCTGGGATCGGCAGACT
TCTACAAGAGCATGACGACGTATCGGGACCACCGCGTCTGGCAGGATGTGTATCACCCGAGCACACCTTATGGGAGCCTT
TACGTGAAGTTGACCGTTCAGGACGATTTGCTCGTCGTGTCGTTCAAGGTACGGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT168541 WP_000063156.1 NZ_CP059288:c3931924-3931622 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp

>AT168541 NZ_CP076060:186302-186703 [Cupriavidus sp. EM10]
ATGAGATGCCCGGAATGTGGCGGCGCGGATCTGGTCAAGGGGCGGCGTGACTTGCCTTATACCTATCGCGGGGAGTCGAC
TGTGGTCGAGGACGTGGAAGGAGAGTGGTGCCCGCTTTGCGGCGAAGGAGTGCTTTCCCGTGAAGCGCACGAACGTCTCG
ACGACGTCGCGCTGGCCTTTAACAAGCAGGTCAACGCGTCCTTGGTCGACCCCACTTTCATCGTCTCGGTGCGCAAGAAG
CTGCGTCTGGACCAGAAGGAGGCCGGAGAAATTTTCGGCGGCGGCGTGAATGCGTTTTCGCGCTATGAGACCGGGCGGAC
CAAGCCGCCCCTGTCTCTGGTCCAATTGCTCAAGCTGCTCGATCGCCACCCGGACCTGCTCGATGAGCTACGTGCTGGTT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A829G8Z0

References