Detailed information of TA system TA168489

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4847132..4847966
• Replicon: chromosome
• Accession: NZ_CP059281
• Organism: Escherichia coli strain C9

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: H0272_RS23390
• Protein ID: WP_001546109.1
• Coordinates: 4847589..4847966 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A7I0L0C8
• Locus tag: H0272_RS23385
• Protein ID: WP_001546108.1
• Coordinates: 4847132..4847512 (+)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0272_RS23350	4843412..4843867	+	456	WP_001545736.1	hypothetical protein	-
H0272_RS23355	4843946..4844179	+	234	WP_001119729.1	DUF905 family protein	-
H0272_RS23360	4844279..4845097	+	819	WP_001234620.1	DUF945 domain-containing protein	-
H0272_RS23365	4845152..4845637	+	486	WP_000849588.1	antirestriction protein	-
H0272_RS23370	4845653..4846129	+	477	WP_001424026.1	RadC family protein	-
H0272_RS23375	4846198..4846419	+	222	WP_000692345.1	DUF987 domain-containing protein	-
H0272_RS23380	4846438..4847082	+	645	WP_000086755.1	hypothetical protein	-
H0272_RS23385	4847132..4847512	+	381	WP_001546108.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
H0272_RS23390	4847589..4847966	+	378	WP_001546109.1	TA system toxin CbtA family protein	Toxin
H0272_RS23395	4847963..4848450	+	488	Protein_4566	hypothetical protein	-
H0272_RS23400	4848467..4848664	+	198	WP_042024643.1	DUF957 domain-containing protein	-
H0272_RS23405	4848749..4849594	+	846	WP_001529401.1	DUF4942 domain-containing protein	-
H0272_RS23410	4849663..4850058	+	396	WP_000208384.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	-
H0272_RS23415	4850051..4850984	+	934	Protein_4570	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
H0272_RS23420	4851416..4851571	+	156	WP_000729638.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	4851416..4851571	155

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13986.00 Da
• Isoelectric Point: 8.5190

>T168489 WP_001546109.1 NZ_CP059281:4847589-4847966 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYKMVNNITQGKHPEAKR

Nucleotide

• Length: 378 bp

>T168489 NZ_CP076027:c1991065-1990913 [Staphylococcus sp. MZ7]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 13997.78 Da
• Isoelectric Point: 5.0823

>AT168489 WP_001546108.1 NZ_CP059281:4847132-4847512 [Escherichia coli]
MSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFNNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Nucleotide

• Length: 381 bp

>AT168489 NZ_CP076027:c1991689-1991090 [Staphylococcus sp. MZ7]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A7I0L0C8