Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4695085..4695739 Replicon chromosome
Accession NZ_CP059281
Organism Escherichia coli strain C9

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag H0272_RS22615 Protein ID WP_000244765.1
Coordinates 4695085..4695492 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag H0272_RS22620 Protein ID WP_000354050.1
Coordinates 4695473..4695739 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0272_RS22595 4691042..4692775 - 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -
H0272_RS22600 4692781..4693491 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
H0272_RS22605 4693516..4694412 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
H0272_RS22610 4694524..4695045 + 522 WP_001055874.1 flavodoxin FldB -
H0272_RS22615 4695085..4695492 - 408 WP_000244765.1 protein YgfX Toxin
H0272_RS22620 4695473..4695739 - 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
H0272_RS22625 4695982..4696962 + 981 WP_000886080.1 tRNA-modifying protein YgfZ -
H0272_RS22630 4697039..4697698 - 660 WP_000250275.1 hemolysin III family protein -
H0272_RS22635 4697862..4698173 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
H0272_RS22640 4698218..4699651 + 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T168488 WP_000244765.1 NZ_CP059281:c4695492-4695085 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T168488 NZ_CP076027:1136694-1136945 [Staphylococcus sp. MZ7]
ATGAATAACCGCGAACAAATTGAACAATCAATTATCAGTGCTAGTGCCTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGGTTGAAGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGATGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT168488 WP_000354050.1 NZ_CP059281:c4695739-4695473 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT168488 NZ_CP076027:1136935-1137108 [Staphylococcus sp. MZ7]
ATGAGTATTAGTGTAGGAGATAAAGTGTATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCCGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References