168472

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2726407..2726878 Replicon chromosome
Accession NZ_CP059281
Organism Escherichia coli strain C9

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag H0272_RS13075 Protein ID WP_001303511.1
Coordinates 2726407..2726685 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag H0272_RS13080 Protein ID WP_001302048.1
Coordinates 2726687..2726878 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0272_RS13040 2721620..2721889 - 270 WP_000003742.1 excisionase -
H0272_RS13045 2721951..2724389 - 2439 WP_000102132.1 exonuclease -
H0272_RS13050 2724482..2724670 - 189 WP_000199475.1 DUF1482 family protein -
H0272_RS13055 2724667..2724855 - 189 WP_000449175.1 cell division inhibitor -
H0272_RS13060 2725431..2725625 + 195 WP_001295058.1 hypothetical protein -
H0272_RS13065 2725614..2725952 - 339 WP_000394541.1 hypothetical protein -
H0272_RS13070 2725964..2726116 - 153 WP_000380313.1 DUF1391 family protein -
H0272_RS13075 2726407..2726685 - 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H0272_RS13080 2726687..2726878 - 192 WP_001302048.1 hypothetical protein Antitoxin
H0272_RS13085 2726899..2727270 - 372 WP_001169687.1 hypothetical protein -
H0272_RS13090 2727368..2727670 + 303 WP_001556930.1 transcriptional regulator -
H0272_RS13095 2727667..2728092 + 426 WP_000693943.1 Rha family transcriptional regulator -
H0272_RS13100 2728115..2729077 + 963 WP_000095673.1 helix-turn-helix domain-containing protein -
H0272_RS13105 2729084..2729830 + 747 WP_000788950.1 ATP-binding protein -
H0272_RS13110 2729852..2730622 + 771 WP_000450998.1 DUF1627 domain-containing protein -
H0272_RS13115 2730638..2731060 + 423 Protein_2547 DUF977 family protein -
H0272_RS13120 2731166..2731378 + 213 WP_000072553.1 hypothetical protein -
H0272_RS13125 2731411..2731629 + 219 WP_001610644.1 DUF4014 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T168472 WP_001303511.1 NZ_CP059281:c2726685-2726407 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

>T168472 NZ_CP076025:c834923-834735 [Staphylococcus sp. MZ1]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT168472 WP_001302048.1 NZ_CP059281:c2726878-2726687 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp

>AT168472 NZ_CP076025:c835212-834952 [Staphylococcus sp. MZ1]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
AlphaFold DB A0A829CTP0

References