Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2057273..2057891 Replicon chromosome
Accession NZ_CP059281
Organism Escherichia coli strain C9

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag H0272_RS09880 Protein ID WP_001291435.1
Coordinates 2057273..2057491 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag H0272_RS09885 Protein ID WP_000344800.1
Coordinates 2057517..2057891 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0272_RS09845 2052561..2053133 + 573 WP_000779841.1 YbaY family lipoprotein -
H0272_RS09850 2053164..2053475 - 312 WP_000409908.1 MGMT family protein -
H0272_RS09860 2053854..2054207 + 354 WP_000878147.1 DUF1428 family protein -
H0272_RS09865 2054249..2055799 - 1551 WP_001545832.1 cyclic-guanylate-specific phosphodiesterase PdeB -
H0272_RS09870 2055963..2056433 - 471 WP_000136192.1 YlaC family protein -
H0272_RS09875 2056549..2057100 - 552 WP_000102539.1 maltose O-acetyltransferase -
H0272_RS09880 2057273..2057491 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
H0272_RS09885 2057517..2057891 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
H0272_RS09890 2058437..2061586 - 3150 WP_001132478.1 multidrug efflux RND transporter permease subunit -
H0272_RS09895 2061609..2062802 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T168470 WP_001291435.1 NZ_CP059281:c2057491-2057273 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T168470 NZ_CP076024:c1163223-1163026 [Methylobacter sp. S3L5C]
ATGAAAATAGTCTGGACTGAGCCTGCCCGTCAAGATTTACGTGATATTTTTACTTACATTGCCGAAAATAATCCCAAAAC
AGCACGAAAGCTACTCAACGACATAAAAGAGCGTACCGTTTTACTTCAGGATAATCCCTTAATAGGGCGCTTGGGGCGCA
TTGAAGACACCCGCGAATTAGTGCTGATCGGTACATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT168470 WP_000344800.1 NZ_CP059281:c2057891-2057517 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT168470 NZ_CP076024:c1163478-1163278 [Methylobacter sp. S3L5C]
ATGGCAACCGAAGCATTTAGTATTAGAGTCGAAACAGAAATCATCCATAAACTGGATAACCTTGCCGGATCACTGGACAG
ATCGCGCAATTATTTGGTTAATCAGGCTATAAAAGCCTATCTGCAAGCCAACGCTTCGGCTTGTGCCAAGATCACCCAAA
GGTATAGCGGCAGCAAATCGTGGCGAATTCGTTGTCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References