Detailed information of TA system TA168469

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 1907134..1908823
• Replicon: chromosome
• Accession: NZ_CP059281
• Organism: Escherichia coli strain C9

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: H0272_RS09150
• Protein ID: WP_000365807.1
• Coordinates: 1907903..1908823 (+)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: H0272_RS09145
• Protein ID: WP_001295795.1
• Coordinates: 1907134..1907916 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0272_RS09140	1903752..1906850	-	3099	WP_000673070.1	type I restriction endonuclease subunit R	-
H0272_RS09145	1907134..1907916	+	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
H0272_RS09150	1907903..1908823	+	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
H0272_RS09155	1908988..1910307	-	1320	Protein_1774	site-specific integrase	-
H0272_RS09160	1910534..1910692	-	159	Protein_1775	integrase	-
H0272_RS09165	1910741..1910926	+	186	WP_000146240.1	hypothetical protein	-
H0272_RS09170	1911141..1911755	+	615	WP_001019923.1	YagU family protein	-
H0272_RS09175	1911829..1911992	+	164	Protein_1778	tail fiber assembly protein	-
H0272_RS09180	1912004..1912333	-	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
H0272_RS09185	1912640..1913350	-	711	WP_001295798.1	fimbrial chaperone EcpE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T168469 WP_000365807.1 NZ_CP059281:1907903-1908823 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

>T168469 NZ_CP076024:30909-31232 [Methylobacter sp. S3L5C]
ATGAGGCGAGGTGATCTGGTAACGATTGTGTTGCAAGGCGCTTATGGTAAACCGCGTCCCGCCTTGATCATTCAGTCAGA
TTTATTTTCTGAGCATCCCTCCGTAACCATCATTCCAATCACCAGTGAGTTGCGGGATACACCATTGTTTCGTGTTCCGG
TTAGGTATGGCGAAAGTACAGGGCTAAGAAAACCGTCAGAAATCATGATAGATAAGGTACAAACCATTCCACGCGAAAAA
ATAGGGGCCGTGTTTGGACGTCTAGCGGAAGAAGATATGTTGGCCGTTAATCGGGCATTAGCCGTGTTCCTGGGTGTTGT
ATAA

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT168469 WP_001295795.1 NZ_CP059281:1907134-1907916 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

>AT168469 NZ_CP076024:30697-30912 [Methylobacter sp. S3L5C]
ATGACTACCAAGACAACTGCTGATCGAGTGCAAAAACATCGGGCCGGGCTACGAGCTGCCGGACTACGTCCTGTGCAGAT
ATGGGTTCCAGATACACGGAGTACCGGCTTTGCGGATGAATGCCGCCGTCAATCCCTTGCCCTGCAAGGCGACCCACAAG
AAACCGACATGGCAAACTGGCTGGAAGCTTCGGCTGACACCAAGGGGTGGGAATGA

Structures

Toxin

• AlphaFold DB: A0A061KTE0