168468

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1641165..1641715 Replicon chromosome
Accession NZ_CP059281
Organism Escherichia coli strain C9

Toxin (Protein)


Gene name ccdB Uniprot ID S1PDG4
Locus tag H0272_RS07815 Protein ID WP_001160966.1
Coordinates 1641401..1641715 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag H0272_RS07810 Protein ID WP_000125566.1
Coordinates 1641165..1641398 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0272_RS07785 1636238..1636525 + 288 WP_000203741.1 ferredoxin-like protein FixX -
H0272_RS07790 1636584..1637915 + 1332 WP_001183207.1 MFS transporter -
H0272_RS07795 1638023..1638553 + 531 WP_000600725.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
H0272_RS07800 1638546..1640408 + 1863 WP_000377124.1 glutathione-regulated potassium-efflux system protein KefC -
H0272_RS07805 1640600..1641079 + 480 WP_000624375.1 type 3 dihydrofolate reductase -
H0272_RS07810 1641165..1641398 + 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
H0272_RS07815 1641401..1641715 + 315 WP_001160966.1 CcdB family protein Toxin
H0272_RS07820 1641712..1642560 - 849 WP_000257181.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
H0272_RS07825 1642567..1642944 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
H0272_RS07830 1642947..1643768 - 822 WP_001065363.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
H0272_RS07835 1643765..1644754 - 990 WP_000241227.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
H0272_RS07840 1644754..1646040 - 1287 WP_000800457.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11711.72 Da        Isoelectric Point: 9.0851

>T168468 WP_001160966.1 NZ_CP059281:1641401-1641715 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

>T168468 NZ_CP076023:c3283095-3282790 [Cellulomonas dongxiuzhuiae]
ATGCGGCCCATCCACGTCGCCGAGCTCGACAAGGCGCGACCGGTGCTCGTCCTCACGCGAGAGCTCGTGCGTCCCCACCT
GTCGAGCGTCACGGTGGCGCCGATCACCACCACCGTGCGGGGGCTGTCCACCGAGGTGCCCCTCGGCCGCGCGAACGGGC
TCGACCAGGACTGCGTCGTGAGCTGCGACAACGTCCAGACCGTGCCCGCGTCGGCGCTCGGACGGCAGATCGGCTACCTG
CTGCCCGACCAGGAGGCCCGGCTCGCGCTGGCCATCGCCCTGGCCTTCGACCTGGAGCCGGAGTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT168468 WP_000125566.1 NZ_CP059281:1641165-1641398 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp

>AT168468 NZ_CP076023:c3283334-3283095 [Cellulomonas dongxiuzhuiae]
ATGACGATCCAGATCACCGTGCGCCTGGACGACGACCTCGTCCAGGCTGTCGACGCGCTCGTGGCCGAGGGACGCGCGCG
CAGCCGTGCGGCGGTCGTCGAGGTCGCCCTCGAGCGTCACCTCCGACGTGAGCTCGCGACGCGGGACGTCGAGATCCTGC
GCGGAGACCCGTCCGGCACGGACCTCGACGCGCTCGCCGCATGGAGTCACCAGCTGCCCGCACCACGCGGGCTCGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G815

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References