Detailed information of TA system TA168466

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 1491697..1492517
• Replicon: chromosome
• Accession: NZ_CP059281
• Organism: Escherichia coli strain C9

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: H0272_RS07070
• Protein ID: WP_001054379.1
• Coordinates: 1492260..1492517 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: H0272_RS07065
• Protein ID: WP_000123957.1
• Coordinates: 1491697..1492248 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0272_RS07040	1487391..1488704	-	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-
H0272_RS07045	1488716..1488994	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
H0272_RS07050	1488991..1490112	-	1122	WP_000010833.1	M42 family metallopeptidase	-
H0272_RS07055	1490511..1490771	-	261	WP_000077645.1	hypothetical protein	-
H0272_RS07060	1490899..1491645	-	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
H0272_RS07065	1491697..1492248	-	552	WP_000123957.1	N-acetyltransferase	Antitoxin
H0272_RS07070	1492260..1492517	-	258	WP_001054379.1	YjhX family toxin	Toxin
H0272_RS07075	1492894..1493193	-	300	WP_001332034.1	GNAT family N-acetyltransferase	-
H0272_RS07080	1493271..1494002	+	732	Protein_1370	DNA helicase	-
H0272_RS07085	1494032..1495645	-	1614	WP_000080195.1	IS66-like element ISEc23 family transposase	-
H0272_RS07090	1495676..1496026	-	351	WP_000624722.1	IS66 family insertion sequence element accessory protein TnpB	-
H0272_RS07095	1496023..1496448	-	426	WP_000422741.1	IS66 family insertion sequence hypothetical protein	-
H0272_RS07100	1496576..1497037	+	462	WP_012896898.1	phospholipase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T168466 WP_001054379.1 NZ_CP059281:c1492517-1492260 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T168466 NZ_CP076009:c14266-13916 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT168466 WP_000123957.1 NZ_CP059281:c1492248-1491697 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT168466 NZ_CP076009:c13911-13609 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Structures

Toxin

• AlphaFold DB: B6I030