Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 665865..666697 Replicon chromosome
Accession NZ_CP059281
Organism Escherichia coli strain C9

Toxin (Protein)


Gene name yeeV Uniprot ID E3PN67
Locus tag H0272_RS03240 Protein ID WP_000854775.1
Coordinates 666323..666697 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A426P7N5
Locus tag H0272_RS03235 Protein ID WP_001285645.1
Coordinates 665865..666233 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0272_RS03200 661688..662368 + 681 WP_001282911.1 WYL domain-containing protein -
H0272_RS03205 662519..663196 + 678 WP_001097567.1 hypothetical protein -
H0272_RS03210 663202..663435 + 234 WP_001278284.1 DUF905 family protein -
H0272_RS03215 663525..664343 + 819 WP_001175173.1 DUF945 domain-containing protein -
H0272_RS03220 664435..664920 + 486 WP_000213721.1 antirestriction protein -
H0272_RS03225 664936..665412 + 477 WP_001318130.1 RadC family protein -
H0272_RS03230 665481..665702 + 222 WP_000692303.1 DUF987 domain-containing protein -
H0272_RS03235 665865..666233 + 369 WP_001285645.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
H0272_RS03240 666323..666697 + 375 WP_000854775.1 TA system toxin CbtA family protein Toxin
H0272_RS03245 666694..667185 + 492 WP_000976825.1 hypothetical protein -
H0272_RS03250 667197..667394 + 198 WP_000772035.1 DUF957 domain-containing protein -
H0272_RS03255 667479..668321 + 843 WP_001274548.1 DUF4942 domain-containing protein -
H0272_RS03260 668917..669414 + 498 WP_000509815.1 hypothetical protein -
H0272_RS03265 669592..670515 + 924 WP_000535950.1 carboxylate/amino acid/amine transporter -
H0272_RS03270 670519..671337 - 819 WP_000779409.1 lipoprotein NlpA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13965.02 Da        Isoelectric Point: 8.2830

>T168463 WP_000854775.1 NZ_CP059281:666323-666697 [Escherichia coli]
MKTLPDTLVREASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

>T168463 NZ_CP076008:c4845302-4845018 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13678.37 Da        Isoelectric Point: 5.4492

>AT168463 WP_001285645.1 NZ_CP059281:665865-666233 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRADIRGRFSDADAYHLDQAFPLLMKQLELMLTNG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT168463 NZ_CP076008:c4845534-4845292 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E3PN67

Antitoxin

Source ID Structure
AlphaFold DB A0A426P7N5

References