Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4149441..4150095 Replicon chromosome
Accession NZ_CP059279
Organism Escherichia coli strain C7

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag H0271_RS19960 Protein ID WP_000244765.1
Coordinates 4149441..4149848 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag H0271_RS19965 Protein ID WP_000354050.1
Coordinates 4149829..4150095 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0271_RS19940 4145398..4147131 - 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -
H0271_RS19945 4147137..4147847 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
H0271_RS19950 4147872..4148768 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
H0271_RS19955 4148880..4149401 + 522 WP_001055874.1 flavodoxin FldB -
H0271_RS19960 4149441..4149848 - 408 WP_000244765.1 protein YgfX Toxin
H0271_RS19965 4149829..4150095 - 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
H0271_RS19970 4150338..4151318 + 981 WP_000886080.1 tRNA-modifying protein YgfZ -
H0271_RS19975 4151395..4152054 - 660 WP_000250275.1 hemolysin III family protein -
H0271_RS19980 4152218..4152529 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
H0271_RS19985 4152574..4154007 + 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T168450 WP_000244765.1 NZ_CP059279:c4149848-4149441 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T168450 NZ_CP075897:c1512121-1511852 [Exiguobacterium acetylicum]
ATGACAGCATATACGGTAGAGTTTGAGCGCGGAGCTCAAAAGTCTCTCAAGAAGATGGACCCTCAACAAGCGCGGATCAT
CATGTCCTGGATCAAGAAGAATCTGGTCGGGACGGATGATCCGCGTCGTCATGGTAGAGGGCTCGTCTCGAACAGATCGG
GTGAATGGCGTTATCGCATCGGTGATTATCGTCTGATTGCTGACATCCAGGATGAAAAAGTCGTGATCTTAATTCTCGAA
ATAGGACACCGTCGAGATATTTACAAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT168450 WP_000354050.1 NZ_CP059279:c4150095-4149829 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT168450 NZ_CP075897:c1512342-1512118 [Exiguobacterium acetylicum]
ATGAGTACCATTTCCGTACGTCTAGATGATCAAGATACACGACTCATCAAGGAATATGCGAAAGCGAAGAACATCACGAT
TTCTACACTCGTTCGCGATGCCGTCCTCGACCGTATCGAAGATGAAATCGATTTACAACTCTATCATGATTCGATGGCAG
CACACCGTAAAAAATCAGAAGCGATCTCTTTCGACGATATGATGAAAGAACTTGATTTAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References